Babayeva Mariana, Assefa Haregewein, Basu Paramita, Chumki Sanjeda, Loewy Zvi
Touro College of Pharmacy, 230 West 125th Street, Room 530, New York, NY 10027, USA.
Parkinsons Dis. 2016;2016:1279042. doi: 10.1155/2016/1279042. Epub 2016 Dec 5.
Parkinson's disease (PD), a neurodegenerative disorder, is the second most common neurological illness in United States. Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency. This therapy improves only motor symptoms of Parkinson's disease and is associated with a number of adverse effects including dyskinesia. Therefore, there is unmet need for more comprehensive approach in the management of PD. Cannabis and related compounds have created significant research interest as a promising therapy in neurodegenerative and movement disorders. In this review we examine the potential benefits of medical marijuana and related compounds in the treatment of both motor and nonmotor symptoms as well as in slowing the progression of the disease. The potential for cannabis to enhance the quality of life of Parkinson's patients is explored.
帕金森病（PD）是一种神经退行性疾病，是美国第二常见的神经系统疾病。在神经学上，它的特征是一组独特的细胞——黑质纹状体多巴胺神经元选择性退化。目前的治疗是对症治疗，主要涉及补充多巴胺缺乏。这种疗法仅改善帕金森病的运动症状，并且伴有包括运动障碍在内的多种不良反应。因此，在帕金森病的管理方面，对更全面方法的需求尚未得到满足。大麻及相关化合物作为神经退行性疾病和运动障碍的一种有前景的疗法，引起了大量研究兴趣。在本综述中，我们研究了医用大麻及相关化合物在治疗运动和非运动症状以及减缓疾病进展方面的潜在益处。探讨了大麻改善帕金森病患者生活质量的可能性。
