Kapitola J, Jahoda I, Kubícková J
Cas Lek Cesk. 1989 Sep 8;128(37):1175-7.
The authors investigated in three experiments the blood flow (by retention of 85Sr microparticles), the 85Sr retention and state of mineralization of the tibia in female rats after oophorectomy (OOX). In the first experiment one month after OOX the retention of 85Sr microparticles is increased significantly to 158.6%, as compared with controls, the blood flow is increased insignificantly to 131.3%. In the second experiment the retention of microparticles is increased maximally 4 weeks after OOX to 152.9%, the blood flow after two weeks to 150.0%, as compared with controls; the weight of the ash per unit of bone volume of the tibia is significantly reduced after 8 weeks following OOX--to 90.8%. The two-hour retention of radioactive strontium 85Sr in the third experiment after OOX rises--significantly after 8 weeks to 133.4%. The results of the experiments are consistent with the idea on an increased metabolic activity of osseous tissue in the initial stage of the demineralization process following OOX.
作者通过三项实验研究了去卵巢（OOX）后雌性大鼠的血流量（通过85Sr微粒滞留）、85Sr滞留以及胫骨的矿化状态。在第一项实验中，去卵巢一个月后，与对照组相比，85Sr微粒的滞留显著增加至158.6%，血流量无显著增加，为131.3%。在第二项实验中，与对照组相比，去卵巢4周后微粒滞留最大增加至152.9%，两周后血流量增加至150.0%；去卵巢8周后，胫骨单位骨体积的灰重显著降低至90.8%。在第三项实验中，去卵巢后8周，放射性锶85Sr的两小时滞留显著上升至133.4%。实验结果与去卵巢后脱矿过程初始阶段骨组织代谢活性增加的观点一致。
