Shankar Kiran, Kumar Durgesh, Kumar Kariyanakatte Veeraiah Veerendra, Premlata Chennagiri
Senior Resident, Department of Surgical Oncology, Kidwai Memorial Institute of Oncology , Bangalore, Karnataka, India .
Professor, Department of Surgical Oncology, Kidwai Memorial Institute of Oncology , Bangalore, Karnataka, India .
J Clin Diagn Res. 2016 Nov;10(11):XD01-XD02. doi: 10.7860/JCDR/2016/21946.8916. Epub 2016 Nov 1.
Renal Cell Carcinoma (RCC) accounts for 5% of the epithelial malignancies worldwide with clear cell carcinoma accounting for 85% of these malignancies. One third of these patients experience synchronous metastatic disease and 20-30% of the remaining patients experience metachronous metastatic RCC. Bony metastasis accounts for 20% of metastatic RCC. They most commonly affect the axial skeleton and rarely the long bones or the small bones of the hands and feet. Bone metastases from RCC are predominantly osteolytic in nature, leading to significant patient morbidity due to the associated Skeletal Related Events (SRE). SREs may significantly decrease patient quality of life. Bone pain is most common SRE and radiotherapy is most common form of treatment. Only 2% of the patients require surgery. Here we present a case of advanced RCC with tibial and ankle metastasis who presented to us after one year of radical nephrectomy with severe pain and inability to walk and underwent above knee amputation.
肾细胞癌（RCC）占全球上皮性恶性肿瘤的5%，其中透明细胞癌占这些恶性肿瘤的85%。这些患者中有三分之一发生同步转移性疾病，其余患者中有20%-30%发生异时性转移性RCC。骨转移占转移性RCC的20%。它们最常累及中轴骨骼，很少累及长骨或手和脚的小骨。RCC的骨转移本质上主要是溶骨性的，由于相关的骨相关事件（SRE）导致患者出现明显的发病率。SRE可能会显著降低患者的生活质量。骨痛是最常见的SRE，放射治疗是最常见的治疗形式。只有2%的患者需要手术。在此，我们报告一例晚期RCC伴胫骨和踝关节转移的病例，该患者在根治性肾切除术后一年因剧痛和无法行走前来就诊，并接受了膝上截肢手术。
