Nicita Francesco, Paiano Milena, Liberatore Mauro, Spalice Alberto, Papoff Paola, Ullo Mariacristina, Piccirilli Manolo, Clerico Anna, Schiavetti Amalia
Child Neurology Division, Department of Pediatrics and Child Neuropsychiatry, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena 324, 00161, Roma, Italy.
Pediatric Oncology Division, Department of Pediatrics and Child Neuropsychiatry, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Acta Neurochir (Wien). 2017 Mar;159(3):475-479. doi: 10.1007/s00701-016-3059-y. Epub 2017 Jan 3.
Post-operative pediatric cerebellar mutism syndrome (PPCMS) is a clinical syndrome arising from cerebellar injury and characterized by absence of speech and other possible symptoms and signs. Rare reports described some benefit after administration of dopamine agonist therapy, but no treatment has proven efficacy. In this paper, we report on the dramatic, sudden resolution of PPCMS induced by midazolam administration in a boy who underwent posterior fossa surgery for choroid plexus papilloma of the fourth ventricle. In addition to clinical improvement, post-midazolam single-photon emission computed tomography also demonstrated amelioration of brain perfusion.
小儿术后小脑缄默综合征（PPCMS）是一种由小脑损伤引起的临床综合征，其特征为言语缺失及其他可能的症状和体征。罕见报道称多巴胺激动剂治疗后有一定益处，但尚无治疗被证实有效。在本文中，我们报告了一例因第四脑室脉络丛乳头状瘤接受后颅窝手术的男孩，在给予咪达唑仑后PPCMS戏剧性地突然缓解。除了临床改善外，咪达唑仑给药后的单光子发射计算机断层扫描也显示脑灌注有所改善。
