Khalfallah Mehdi, Jerraya Hichem, Sbai Akram, Dougaz Wejih, Changuel Amel, Nouira Ramzi, Bouasker Ibtissem, Dziri Chadli
Tunis Med. 2016 Jul;94(7):401-405.
Background - The Prognostic Nutritional Index (PNI) score is based on the level of lymphocytes and albuminemia. The aim of this study was to validate the pre-operative PNI score for predicting post-operative mortality and morbidity of patients operated on for gastric cancer. Methods - This retrospective study collected data from patients operated on for a gastric cancer at the surgical unit B of Charles Nicolle's hospital in Tunis between January 1st, 2008 and December 31, 2012. The main outcome measure was post-operative death within 30 days. The secondary outcome was post-operative morbidity (within 30 days). We have performed a descriptive analysis, a univariate and multivariate analysis with logistic regression and a ROC curve analysis. Results - 14 women and 26 men were enrolled, with a sex ratio of 1,85. The mean age was 63 ± 15. Post-operative mortality and morbidity rate were respectively 18% and 28%. The ROC curve allowed us to validate the PNI for predicting post-operative mortality in gastric cancer with a threshold level of 38 with sensitivity 100% and specificity 64%. PNI was also validated for post-operative morbidity with a threshold level of 38 with sensitivity 82% and specificity 66%. Conclusion - PNI was validated for predicting post-operative mortality and post-operative morbidity in gastric cancer.
背景 - 预后营养指数（PNI）评分基于淋巴细胞水平和白蛋白血症。本研究的目的是验证术前PNI评分对预测胃癌手术患者术后死亡率和发病率的有效性。方法 - 这项回顾性研究收集了2008年1月1日至2012年12月31日期间在突尼斯查尔斯·尼科勒医院外科B单元接受胃癌手术患者的数据。主要结局指标是30天内的术后死亡。次要结局是术后发病率（30天内）。我们进行了描述性分析、单因素和多因素逻辑回归分析以及ROC曲线分析。结果 - 共纳入14名女性和26名男性，性别比为1.85。平均年龄为63±15岁。术后死亡率和发病率分别为18%和28%。ROC曲线使我们能够验证PNI对预测胃癌术后死亡率的有效性，阈值水平为38，敏感性为100%，特异性为64%。PNI对术后发病率也有效，阈值水平为38，敏感性为82%，特异性为66%。结论 - PNI被验证可用于预测胃癌术后死亡率和术后发病率。
