Martínková J, Dolezalová K, Kopecká J
Cesk Pediatr. 1989 Sep;44(9):539-42.
On the case of a 13-year-old boy the authors demonstrate the possible non-linear relationship between long-term administration of theophylline and its serum concentrations which implies the danger of induction of limital to toxic concentrations of the drug in the blood stream when the doses are increased as required.
在一名13岁男孩的病例中，作者证明了长期服用茶碱与其血清浓度之间可能存在非线性关系，这意味着当按要求增加剂量时，有导致药物在血流中达到极限至中毒浓度的风险。
