O'Connor Megan A, Rastad Jessica L, Green William R
1 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon , New Hampshire.
2 Norris Cotton Cancer Center , Geisel School of Medicine at Dartmouth, Lebanon , New Hampshire.
Viral Immunol. 2017 Mar;30(2):82-97. doi: 10.1089/vim.2016.0125. Epub 2017 Jan 4.
Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that are well described as potent immune regulatory cells during human cancer and murine tumor models. Reports of MDSCs during viral infections remain limited, and their association with immunomodulation of viral diseases is still being defined. Here, we provide an overview of MDSCs or MDSC-like cells identified during viral infections, including murine viral models and human viral diseases. Understanding the similarities and/or differences of virally induced versus tumor-derived MDSCs will be important for designing future immunotherapeutic approaches.
髓系来源的抑制性细胞（MDSCs）是异质性的未成熟髓系细胞，在人类癌症和小鼠肿瘤模型中被充分描述为强大的免疫调节细胞。关于病毒感染期间MDSCs的报道仍然有限，它们与病毒性疾病免疫调节的关联仍在确定之中。在这里，我们概述了在病毒感染期间鉴定出的MDSCs或MDSC样细胞，包括小鼠病毒模型和人类病毒性疾病。了解病毒诱导的MDSCs与肿瘤来源的MDSCs之间的异同对于设计未来的免疫治疗方法至关重要。
