Wolfe Lisa L, Wood Mary E, Nol Pauline, McCollum Matthew P, Fisher Mark C, Lance William R
1 Colorado Division of Parks and Wildlife, 4330 Laporte Avenue, Fort Collins, Colorado 80521-2153, USA.
2 Wyoming Game and Fish Department, 528 S Adams Street, Laramie, Wyoming 82070, USA.
J Wildl Dis. 2017 Apr;53(2):304-310. doi: 10.7589/2016-05-107. Epub 2017 Jan 4.
We evaluated a combination of nalbuphine, medetomidine, and azaperone (NalMed-A) in 12 American bison ( Bison bison ) during 13 sedation handling events. The mean (SE) dosage was 0.4 (0.02) mg/kg nalbuphine, 0.08 (0.003) mg/kg medetomidine, and 0.08 (0.003) mg/kg azaperone contained in an average delivery volume of 0.8 mL/100 kg. Two animals required a supplemental dose for safe handling (additive dose used in calculating means) and a third animal was not adequately sedated despite a supplemental dose. Bison immobilized with NalMed-A showed good sedation in 12 of 13 handling attempts. Advantages of this drug combination included a relatively low delivery volume, rapid antagonism, and minimal regulatory burden for component drugs. The most consistent disadvantage was hypoxemia, and oxygen supplementation is recommended when using this sedative combination in bison.
我们在13次镇静处理事件中，对12头美洲野牛（Bison bison）使用了纳布啡、美托咪定和阿扎哌隆的组合（NalMed - A）。平均（标准误）剂量为每千克体重0.4（0.02）毫克纳布啡、0.08（0.003）毫克美托咪定和0.08（0.003）毫克阿扎哌隆，平均给药体积为每100千克0.8毫升。两只动物需要补充剂量以确保安全处理（计算平均值时使用了追加剂量），第三只动物尽管补充了剂量但镇静效果仍不理想。在13次处理尝试中，有12次使用NalMed - A固定的野牛表现出良好的镇静效果。这种药物组合的优点包括给药体积相对较小、拮抗作用迅速以及成分药物的监管负担最小。最常见的缺点是低氧血症，因此在对野牛使用这种镇静组合时建议进行氧气补充。
