Imamura Y, Higuchi T, Kojima Y, Otagiri M
Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1941-3. doi: 10.1248/cpb.37.1941.
Species and sex differences of acetohexamide reductase activity were investigated using the cytosolic fraction of heart homogenate. The activity in the rabbit was considerably higher than that in the other species (guinea pig, hamster, rat and mouse). No sex difference of the activity was observed in any of the species tested. Ketone-containing drugs (daunorubicin, befunolol and levobunolol) other than acetohexamide were little reduced in the cytosol of rabbit heart. Some aldehyde reductase inhibitors (phenobarbital, valproate and chlorothiazide) were found to decrease the acetohexamide reductase activity in the cytosol of rabbit heart.
利用心脏匀浆的胞质部分研究了醋磺己脲还原酶活性的种属和性别差异。兔体内的该活性显著高于其他种属（豚鼠、仓鼠、大鼠和小鼠）。在所测试的任何种属中均未观察到该活性的性别差异。除醋磺己脲外，含酮药物（柔红霉素、倍他洛尔和左布诺洛尔）在兔心脏胞质中的还原程度很小。发现一些醛还原酶抑制剂（苯巴比妥、丙戊酸盐和氯噻嗪）可降低兔心脏胞质中的醋磺己脲还原酶活性。
