Mimura T, Nakajima H, Tsujikawa K, Haruyama M, Lee B G, Kohama Y, Kohda I, Iwai M
Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1946-7. doi: 10.1248/cpb.37.1946.
Bis[2-(E-2-alkenoylamino)ethyl] disulfides (compds. I), synthesized from cystamine and 2-trans fatty acids, inhibited collagen-induced rat and rabbit platelet aggregation. The most potent compound was bis[2-(E-2-hexenoylamino)ethyl] disulfide (compd. I-1), and this compound suppressed thromboxane B2 formation from arachidonic acid in rat platelets. The results suggested that compd. I-1 has an inhibitory effect on cyclooxygenase.
由胱胺和2-反式脂肪酸合成的双[2-(E-2-链烯酰氨基)乙基]二硫化物（化合物I）可抑制胶原蛋白诱导的大鼠和兔血小板聚集。最有效的化合物是双[2-(E-2-己烯酰氨基)乙基]二硫化物（化合物I-1），该化合物可抑制大鼠血小板中花生四烯酸生成血栓素B2。结果表明化合物I-1对环氧化酶有抑制作用。
