选择性免疫球蛋白A缺乏症患者中皮肤病的患病率。

Prevalence of dermatologic diseases among patients with selective immunoglobulin A deficiency.

作者信息

Magen Eli, Masalha Atheer, Waitman Dan Andrei, Kahan Natan, Viner Igor, Klassov Leonora, Vardy Daniel

出版信息

Allergy Asthma Proc. 2017 Jan 1;38(1):70-77. doi: 10.2500/aap.2017.38.4018.

DOI:10.2500/aap.2017.38.4018

PMID:28052804

Abstract

BACKGROUND

There are no published large-scale epidemiologic studies regarding the prevalence of skin diseases in patients with selective immunoglobulin A (IgA) deficiency (sIgAD). The purpose of this study was to investigate the prevalence of dermatological diseases in patients with sIgAD.

METHODS

This retrospective matched case-control study was based on data from the Leumit Healthcare Services data base (approximately 725,000 residents of Israel), which was searched for all subjects aged ≥12 years who had undergone serum total IgA measurements during 2004-14 for any reason. The case group included subjects with sIgAD. The control A group was randomly sampled from those subjects in whom an IgA was drawn (n ≈ 725,000), with a ratio of 10 controls for every case (1:10). The control A group was randomly sampled from those subjects in whom an IgA was drawn (n = 104,729) and the control B group was randomly sampled from the full study population (n ≈ 725,000), with a ratio of 10 controls for every case (1:10). Comorbidity was compared between the study groups.

RESULTS

The sIgAD group was characterized: 1) By a higher prevalence of atopic dermatitis (AD) (16 [4.6 %]) than the control A group (76 [2.1 %]; p = 0.004 and the control B group (64 [1.9 %]; p = 0.002). 2) By higher prevalence of acne (69 [19.9 %]) than the control A group (516 [13.8 %]; p = 0.013) and control B group (494 [14.2 %]; p < 0.001). 3) By higher rate of chronic spontaneous urticaria (CSU) (17 [4.9 %)] than in the control A group (31 [0.9 %], with odds ratio 5.54 [3.04-10.13]; p < 0.001) and the control B group (28 [0.8 %]; p < 0.001).

CONCLUSIONS

sIgAD is characterized by a higher prevalence of AD, CSU and acne.

摘要

背景

目前尚无关于选择性免疫球蛋白A（IgA）缺乏症（sIgAD）患者皮肤病患病率的大规模流行病学研究发表。本研究旨在调查sIgAD患者皮肤病的患病率。

方法

这项回顾性匹配病例对照研究基于Leumit医疗服务数据库（约72.5万以色列居民）的数据，在该数据库中搜索了2004年至2014年期间因任何原因进行血清总IgA测量的所有≥12岁的受试者。病例组包括sIgAD患者。对照组A从进行IgA检测的受试者中随机抽取（n≈72.5万），病例与对照的比例为1:10。对照组A从进行IgA检测的受试者中随机抽取（n = 104729），对照组B从整个研究人群中随机抽取（n≈72.5万），病例与对照的比例为1:10。比较研究组之间的合并症情况。

结果

sIgAD组具有以下特点：1）特应性皮炎（AD）的患病率（16例[4.6%]）高于对照组A（76例[2.1%]；p = 0.004）和对照组B（64例[1.9%]；p = 0.002）。2）痤疮的患病率（69例[19.9%]）高于对照组A（516例[13.8%]；p = 0.013）和对照组B（494例[14.2%]；p < 0.001）。3）慢性自发性荨麻疹（CSU）的发生率（17例[4.9%]）高于对照组A（31例[0.9%]，优势比为5.54[3.04 - 10.13]；p < 0.001）和对照组B（28例[0.8%]；p < 0.001）。