The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
QMUL Lipid Mediator Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Nat Rev Rheumatol. 2017 Feb;13(2):87-99. doi: 10.1038/nrrheum.2016.193. Epub 2017 Jan 5.
The past two decades have witnessed major advancements in the clinical management of inflammatory arthritis, with new treatment strategies in some cases providing a marked improvement in patient outcomes. However, it is widely accepted that current strategies do not provide the 'total therapeutic solution', in view of the proportion of patients who do not respond to therapy, the important incidence of adverse effects and the development of an immune response against antibodies or fusion proteins used therapeutically. Moreover, although some therapeutic approaches can effectively bring about an end to inflammation, mechanisms to promote the recovery and/or repair of damage are required. Harnessing the concepts and mechanisms of the resolution of inflammation is a new approach to the treatment of inflammatory pathologies; this approach could help address the unmet need for new therapeutic approaches that not only control but also revert the course of inflammatory rheumatic diseases.
过去二十年见证了炎症性关节炎临床管理的重大进展，一些新的治疗策略在某些情况下显著改善了患者的预后。然而，鉴于有相当一部分患者对治疗没有反应、不良反应的发生率很高以及治疗中使用的抗体或融合蛋白会引发免疫反应，人们普遍认为目前的治疗策略并不能提供“全面的治疗方案”。此外，尽管一些治疗方法可以有效地消除炎症，但还需要促进损伤恢复和/或修复的机制。利用炎症消退的概念和机制是治疗炎症性疾病的一种新方法；这种方法可能有助于满足新的治疗方法的需求，这些方法不仅可以控制，还可以逆转炎症性风湿性疾病的病程。
