血管生成素-1和血管生成素-2在肾血管平滑肌脂肪瘤和PEComa家族性肿瘤中的表达。
Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors.
作者信息
Shrestha Swati, Meyers Carolyn, Shen Jia, Giacomelli Paulina, Scott Michelle A, Soo Chia, Dry Sarah M, Ting Kang, James Aaron W
机构信息
School of Dentistry, University of California, Los Angeles, USA.
Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA.
出版信息
J Orthop. 2016 Dec 27;14(1):154-160. doi: 10.1016/j.jor.2016.12.001. eCollection 2017 Mar.
OBJECTIVE
Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance.
METHODS
Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples.
RESULTS
While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance.
CONCLUSION/IMPLICATIONS: Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.
目的
血管周上皮样细胞肿瘤（PEComa）是一类罕见的软组织肿瘤。此前，我们描述过PEComa家族肿瘤中周细胞抗原的存在因组织学表现而有很大差异。
方法
在此，我们通过在人类肿瘤样本中进行免疫组织化学检测，利用周细胞抗原血管生成素-1（Ang-1）和血管生成素-2（Ang-2）扩展我们的研究结果。
结果
虽然Ang-1在任何PEComa家族肿瘤中均未显示表达，但Ang-2显示出的表达情况与其他周细胞标志物一样，很大程度上由细胞形态决定。
结论/启示：PEComa中周细胞标志物的表达可能代表真正的周细胞起源，或者是异常的周细胞标志物采用。
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