Oshikata Chiyako, Watanabe Maiko, Saito Akemi, Yasueda Hiroshi, Akiyama Kazuo, Kamata Yoichi, Tsurikisawa Naomi
National Hospital Organization Saitama National Hospital, Department of Respirology, 2-1 Suwa, Wako, Saitama 351-0102, Japan; National Hospital Organization Sagamihara National Hospital, Department of Allergy and Respirology, Sakuradai 18-1, Minami-ku, Sagamihara, Kanagawa 252-0392, Japan.
Division of Microbiology, National Institute of Health Science, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Med Mycol Case Rep. 2016 Dec 2;15:9-11. doi: 10.1016/j.mmcr.2016.11.007. eCollection 2017 Mar.
A 65-year-old Japanese male had severe bronchial asthma had increased mold-containing sputum. Serum total IgE level had increased to 798 IU/mL and antigen-specific precipitating antibodies to P. luteum and P. notatum were present but not those reactive toward any species of Aspergillus. Chest computed tomography revealed central bronchiectasis and bronchial wall thickness. After antigen-specific provocation with 10 mg/mL of P. luteum, the patient developed asthma exacerbation, but not with A. fumigatus. We present a rare case of Penicillium-induced allergic bronchopulmonary mycosis caused by P. luteum.
一名65岁的日本男性患有严重支气管哮喘，含霉菌痰液增多。血清总IgE水平升至798 IU/mL，存在针对黄青霉和点青霉的抗原特异性沉淀抗体，但对任何曲霉菌种均无反应性抗体。胸部计算机断层扫描显示中央型支气管扩张和支气管壁增厚。用10 mg/mL黄青霉进行抗原特异性激发后，患者哮喘加重，但烟曲霉激发未导致加重。我们报告一例由黄青霉引起的罕见的青霉属诱发的变应性支气管肺真菌病病例。
