前20个阿尔茨海默病风险基因对灰质密度和氟代脱氧葡萄糖正电子发射断层扫描脑代谢的影响。
The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.
作者信息
Stage Eddie, Duran Tugce, Risacher Shannon L, Goukasian Naira, Do Triet M, West John D, Wilhalme Holly, Nho Kwangsik, Phillips Meredith, Elashoff David, Saykin Andrew J, Apostolova Liana G
机构信息
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Alzheimers Dement (Amst). 2016 Dec 19;5:53-66. doi: 10.1016/j.dadm.2016.12.003. eCollection 2016.
INTRODUCTION
We analyzed the effects of the top 20 Alzheimer disease (AD) risk genes on gray-matter density (GMD) and metabolism.
METHODS
We ran stepwise linear regression analysis using posterior cingulate hypometabolism and medial temporal GMD as outcomes and all risk variants as predictors while controlling for age, gender, and ε4 genotype. We explored the results in 3D using Statistical Parametric Mapping 8.
RESULTS
Significant predictors of brain GMD were in the pooled and mild cognitive impairment (MCI); in the MCI; and , , and in the AD groups. Significant predictors of hypometabolism were in the pooled, and , and in the normal control group.
DISCUSSION
Multiple variants showed associations with GMD and brain metabolism. For most genes, the effects were limited to specific stages of the cognitive continuum, indicating that the genetic influences on brain metabolism and GMD in AD are complex and stage dependent.
引言
我们分析了排名前20的阿尔茨海默病（AD）风险基因对灰质密度（GMD）和代谢的影响。
方法
我们进行逐步线性回归分析，以后扣带回低代谢和内侧颞叶GMD作为结果，所有风险变异作为预测因子，同时控制年龄、性别和ε4基因型。我们使用统计参数映射8在三维空间中探索结果。
结果
在合并组和轻度认知障碍（MCI）中，脑GMD的显著预测因子是 ；在MCI中是 ；在AD组中是 、 和 。低代谢的显著预测因子在合并组中是 ，在正常对照组中是 和 。
讨论
多个变异显示出与GMD和脑代谢有关联。对于大多数基因，其影响仅限于认知连续体的特定阶段，这表明AD中基因对脑代谢和GMD的影响是复杂且依赖阶段的。
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