Li Danni, Misialek Jeffrey R, Boerwinkle Eric, Gottesman Rebecca F, Sharrett A Richey, Mosley Thomas H, Coresh Josef, Wruck Lisa M, Knopman David S, Alonso Alvaro
Department of Lab Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Alzheimers Dement (Amst). 2016 Nov 1;6:1-10. doi: 10.1016/j.dadm.2016.09.003. eCollection 2017.
The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African-American cohort.
We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004-2006 and 2011-2013.
After a mean follow-up of 7.3 years, 77 were classified as having MCI and 18 as having dementia. Our study failed to replicate previous findings in this mostly African American cohort, in that the 10 phospholipids/metabolites only achieved a C statistic/AUC of 0.609 in predicting development of MCI or dementia (compared to 0.96) and 0.607 in distinguishing normal from MCI or dementia at the follow-up visit.
A panel of 10 phospholipids/metabolites previously associated with incident dementia was not predictive of MCI or dementia in an independent cohort.
本研究的目的是调查先前确定的10种磷脂/代谢物，它们在白人中可前瞻性预测轻度认知障碍（MCI）或痴呆症，在以非裔美国人为主的队列中是否也具有预测性。
我们对社区动脉粥样硬化风险研究中221名参与者的血浆样本中的188种磷脂/代谢物进行了重复测量，这些参与者97%为非裔美国人，随访时间为2004 - 2006年至2011 - 2013年。
平均随访7.3年后，77人被归类为患有MCI，18人被归类为患有痴呆症。我们的研究未能在这个以非裔美国人为主的队列中重复先前的发现，即这10种磷脂/代谢物在预测MCI或痴呆症的发展时，C统计量/AUC仅为0.609（相比之下为0.96），在随访时区分正常人与MCI或痴呆症患者时为0.607。
先前与新发痴呆症相关的10种磷脂/代谢物组成的检测组在独立队列中不能预测MCI或痴呆症。
