通过硅诱导的森田-贝利斯-希尔曼氟化物的有机催化动力学拆分合成含手性（四唑基）甲基的丙烯酸酯。
Synthesis of chiral (tetrazolyl)methyl-containing acrylates via silicon-induced organocatalytic kinetic resolution of Morita-Baylis-Hillman fluorides.
作者信息
Nishimine Takayuki, Taira Hiromi, Mori Satoru, Matsubara Okiya, Tokunaga Etsuko, Akiyama Hidehiko, Soloshonok Vadim A, Shibata Norio
机构信息
Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Faculty of Medical Technology, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
出版信息
Chem Commun (Camb). 2017 Jan 17;53(6):1128-1131. doi: 10.1039/c6cc08830a.
PMID:28054095
Abstract
Reported herein is a new approach for the asymmetric installation of a (tetrazolyl)methyl group via Si/F activation using organocatalytic kinetic resolution of racemic MBH-fluorides.
摘要
本文报道了一种通过硅/氟活化，利用外消旋MBH氟化物的有机催化动力学拆分，不对称引入（四唑基）甲基的新方法。
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