Solak Berna, Dikicier Bahar Sevimli, Cosansu Nur C, Erdem Teoman
Department of Dermatology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Department of Dermatology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
Int J Dermatol. 2017 Mar;56(3):341-345. doi: 10.1111/ijd.13425. Epub 2017 Jan 4.
In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non-segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively. Demographic data, scores on the Vitiligo Area Score Index (VASI), clinical features, vitiligo disease activity, repigmentation status, presence of any accompanying autoimmune disease, antinuclear antibody (ANA) titers, serum levels of glucose, thyroid-stimulating hormone (TSH), thyroxine (T4) hormone, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-TG) were recorded. The prevalence of halo nevi was significantly higher (P < 0.001) among children than in other patient groups. The prevalence of leukotrichia was higher in adults with adult-onset disease than in either pediatric patients or adults with childhood-onset disease (P = 0.002). Both anti-TG and anti-TPO levels were significantly higher in adults with adult-onset disease than in pediatric patients and adult patients with childhood-onset disease. The prevalence of autoimmune disease was 22.2%. Anti-TG levels were significantly higher in patients with treatment-related repigmentation than in those without repigmentation. This study shows that clinical features and associations with autoimmune disease may vary according to the age of onset of vitiligo.
在白癜风患者中，疾病的临床和实验室特征可能因发病时间而异。仅有少数研究在文献中探讨了这一问题，且结果相互矛盾。本研究的目的是确定非节段性白癜风患者的人口统计学和临床特征，并聚焦疾病发病时间，建立白癜风与自身免疫性疾病之间的关联。对总共224例有完整病历的白癜风患者进行了回顾性评估。记录了人口统计学数据、白癜风面积评分指数（VASI）得分、临床特征、白癜风疾病活动度、色素再生状态、是否存在任何伴随的自身免疫性疾病、抗核抗体（ANA）滴度、血糖水平、促甲状腺激素（TSH）、甲状腺素（T4）激素、抗甲状腺过氧化物酶（抗-TPO）和抗甲状腺球蛋白（抗-TG）。晕痣在儿童中的患病率显著高于其他患者组（P < 0.001）。成人发病的成人患者中白发的患病率高于儿童患者或儿童期发病的成人患者（P = 0.002）。成人发病的成人患者中抗-TG和抗-TPO水平均显著高于儿童患者和儿童期发病的成人患者。自身免疫性疾病的患病率为22.2%。治疗相关色素再生患者的抗-TG水平显著高于无色素再生患者。本研究表明，白癜风的临床特征以及与自身免疫性疾病的关联可能因发病年龄而异。
