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微小RNA在白癜风中的作用：调节因子与治疗靶点

The Role of MicroRNAs in Vitiligo: Regulators and Therapeutic Targets.

作者信息

Li Lili

机构信息

Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

出版信息

Ann Dermatol. 2020 Dec;32(6):441-451. doi: 10.5021/ad.2020.32.6.441. Epub 2020 Nov 11.

DOI:10.5021/ad.2020.32.6.441
PMID:33911786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7875238/
Abstract

Vitiligo is an acquired skin disorder clinically characterized by the progressive appearance of white maculae due to a loss of functioning epidermal melanocytes. Studies have shown that microRNAs (miRNAs) modulate cellular differentiation, proliferation and apoptosis, including immune cell and melanocyte development and functions. The role of miRNAs in the pathogenesis of several immune-related diseases has been explored. Novel approaches to target miRNAs have recently emerged allowing modulation of miRNAs levels in diverse pathological processes, thus making them promising targets for molecular-based diagnostics and therapy. Here, we report the present status of research on miRNAs expression and functional alterations in vitiligo, in order to more fully understand the role of these molecules in vitiligo pathology.

摘要

白癜风是一种获得性皮肤病，临床特征为由于功能性表皮黑素细胞缺失而逐渐出现白色斑片。研究表明，微小RNA（miRNA）可调节细胞分化、增殖和凋亡，包括免疫细胞以及黑素细胞的发育和功能。人们已经探索了miRNA在几种免疫相关疾病发病机制中的作用。最近出现了靶向miRNA的新方法，可在多种病理过程中调节miRNA水平，因此使其成为基于分子的诊断和治疗的有前景的靶点。在此，我们报告白癜风中miRNA表达和功能改变的研究现状，以便更全面地了解这些分子在白癜风病理中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/a59271158eb0/ad-32-441-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/2ab394b9ac50/ad-32-441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/e1f03e0a3c19/ad-32-441-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/a59271158eb0/ad-32-441-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/2ab394b9ac50/ad-32-441-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/e1f03e0a3c19/ad-32-441-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/079d/7875238/a59271158eb0/ad-32-441-g003.jpg

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Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p.长链非编码 RNA FOXD3-AS1 通过海绵吸附 miR-135a-5p 促进结肠腺癌进展并作为竞争性内源性 RNA 调节 SIRT1。
J Cell Physiol. 2019 Dec;234(12):21889-21902. doi: 10.1002/jcp.28752. Epub 2019 May 6.
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