Taylor Richard S, Tarver James E, Foroozani Alireza, Donoghue Philip C J
School of Earth Sciences, University of Bristol, Bristol, UK.
Bioessays. 2017 Feb;39(2). doi: 10.1002/bies.201600113. Epub 2017 Jan 5.
MicroRNAs are non-coding regulators of gene expression and key factors in development, disease, and targets for bioengineering. Consequently, microRNAs have become essential elements of already burgeoning draft plant genome descriptions where their annotation is often particularly poor, contributing unduly to the corruption of public databases. Using the Citrus sinensis as an example, we highlight and review common failings of miRNAome annotations. Understanding and exploiting the role of miRNAs in plant biology will be stymied unless the research community acts decisively to improve the accuracy of miRNAome annotations. We encourage genome annotation teams to do it right or not at all.
微小RNA是基因表达的非编码调节因子，是发育、疾病中的关键因素，也是生物工程的靶点。因此，微小RNA已成为迅速发展的植物基因组草图描述中的重要元素，但其注释往往特别不完善，给公共数据库的质量带来了不当影响。以甜橙为例，我们重点介绍并回顾了微小RNA组注释中常见的缺陷。除非研究界果断采取行动提高微小RNA组注释的准确性，否则理解和利用微小RNA在植物生物学中的作用将会受阻。我们鼓励基因组注释团队要么正确地进行注释，要么干脆不做。
