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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Minami N, Imai Y, Munakata M, Sasaki S, Sekino H, Abe K, Yoshinaga K

Department of Medicine, Tohoku University School of Medicine, Japan.

Clin Exp Pharmacol Physiol Suppl. 1989;15:85-7. doi: 10.1111/j.1440-1681.1989.tb02999.x.

The age-related changes in mean arterial pressure (MAP), heart rate (HR), and baroreflex sensitivity (BRS) were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats from 4 to 20 weeks of age. 2. Intra-arterial blood pressure (BP) was continuously recorded for 24 h in conscious, freely moving rats. Twenty-four hour MAP and HR were calculated by an online computer. Baroreflex sensitivity was measured by phenylephrine infusion. 3. In SHR, BRS was significantly lower than in WKY as early as 4-5 weeks, at which time MAP in SHR was only slightly raised. During subsequent weeks, rapid increase in MAP occurred in SHR, in association with progressive bradycardia. 4. It was concluded that a reduced BRS may be detected in young prehypertensive SHR and this impairment of BRS may be central in origin.

研究了4至20周龄的自发性高血压大鼠（SHR）和Wistar-Kyoto（WKY）大鼠平均动脉压（MAP）、心率（HR）和压力反射敏感性（BRS）的年龄相关变化。2. 在清醒、自由活动的大鼠中连续24小时记录动脉内血压（BP）。通过在线计算机计算24小时MAP和HR。通过注射去氧肾上腺素测量压力反射敏感性。3. 在SHR中，早在4至5周龄时BRS就显著低于WKY，此时SHR的MAP仅略有升高。在随后的几周里，SHR的MAP迅速升高，并伴有进行性心动过缓。4. 得出的结论是，在年轻的高血压前期SHR中可检测到BRS降低，且这种BRS损害可能起源于中枢。

Minami N, Imai Y, Munakata M, Sasaki S, Sekino H, Abe K, Yoshinaga K

Department of Medicine, Tohoku University School of Medicine, Japan.

Clin Exp Pharmacol Physiol Suppl. 1989;15:85-7. doi: 10.1111/j.1440-1681.1989.tb02999.x.

The age-related changes in mean arterial pressure (MAP), heart rate (HR), and baroreflex sensitivity (BRS) were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats from 4 to 20 weeks of age. 2. Intra-arterial blood pressure (BP) was continuously recorded for 24 h in conscious, freely moving rats. Twenty-four hour MAP and HR were calculated by an online computer. Baroreflex sensitivity was measured by phenylephrine infusion. 3. In SHR, BRS was significantly lower than in WKY as early as 4-5 weeks, at which time MAP in SHR was only slightly raised. During subsequent weeks, rapid increase in MAP occurred in SHR, in association with progressive bradycardia. 4. It was concluded that a reduced BRS may be detected in young prehypertensive SHR and this impairment of BRS may be central in origin.

研究了4至20周龄的自发性高血压大鼠（SHR）和Wistar-Kyoto（WKY）大鼠平均动脉压（MAP）、心率（HR）和压力反射敏感性（BRS）的年龄相关变化。2. 在清醒、自由活动的大鼠中连续24小时记录动脉内血压（BP）。通过在线计算机计算24小时MAP和HR。通过注射去氧肾上腺素测量压力反射敏感性。3. 在SHR中，早在4至5周龄时BRS就显著低于WKY，此时SHR的MAP仅略有升高。在随后的几周里，SHR的MAP迅速升高，并伴有进行性心动过缓。4. 得出的结论是，在年轻的高血压前期SHR中可检测到BRS降低，且这种BRS损害可能起源于中枢。