Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London SE1 9RT, UK.
Nat Commun. 2017 Jan 5;8:13850. doi: 10.1038/ncomms13850.
The diversity and activity of leukocytes is controlled by genetic and environmental influences to maintain balanced immune responses. However, the relative contribution of environmental compared with genetic factors that affect variations in immune traits is unknown. Here we analyse 23,394 immune phenotypes in 497 adult female twins. 76% of these traits show a predominantly heritable influence, whereas 24% are mostly influenced by environment. These data highlight the importance of shared childhood environmental influences such as diet, infections or microbes in shaping immune homeostasis for monocytes, B1 cells, γδ T cells and NKT cells, whereas dendritic cells, B2 cells, CD4 T and CD8 T cells are more influenced by genetics. Although leukocyte subsets are influenced by genetics and environment, adaptive immune traits are more affected by genetics, whereas innate immune traits are more affected by environment.
白细胞的多样性和活性受遗传和环境影响的控制，以维持平衡的免疫反应。然而，影响免疫特征变化的环境因素与遗传因素的相对贡献尚不清楚。在这里，我们分析了 497 名成年女性双胞胎的 23394 种免疫表型。这些特征中有 76%主要表现出遗传性影响，而 24%主要受环境影响。这些数据强调了共享的儿童期环境影响（如饮食、感染或微生物）在塑造单核细胞、B1 细胞、γδ T 细胞和 NKT 细胞免疫动态平衡方面的重要性，而树突状细胞、B2 细胞、CD4 T 和 CD8 T 细胞则更多地受遗传因素影响。尽管白细胞亚群受遗传和环境的影响，但适应性免疫特征受遗传的影响更大，而固有免疫特征受环境的影响更大。
