Institute for Biomedical Research and Innovation, National Research Council of Italy (IRIB-CNR), Via Ugo La Malfa 153, 90146 Palermo, Italy.
Azienda Sanitaria Provinciale di Siracusa, Corso Gelone 17, 96100 Siracusa, Italy.
Int J Mol Sci. 2024 Jul 16;25(14):7788. doi: 10.3390/ijms25147788.
Chemical pollution poses a significant threat to human health, with detrimental effects on various physiological systems, including the respiratory, cardiovascular, mental, and perinatal domains. While the impact of pollution on these systems has been extensively studied, the intricate relationship between chemical pollution and immunity remains a critical area of investigation. The focus of this study is to elucidate the relationship between chemical pollution and human immunity. To accomplish this task, this study presents a comprehensive review that encompasses in vitro, ex vivo, and in vivo studies, shedding light on the ways in which chemical pollution can modulate human immunity. Our aim is to unveil the complex mechanisms by which environmental contaminants compromise the delicate balance of the body's defense systems going beyond the well-established associations with defense systems and delving into the less-explored link between chemical exposure and various immune disorders, adding urgency to our understanding of the underlying mechanisms and their implications for public health.
化学污染对人类健康构成重大威胁，对包括呼吸系统、心血管系统、精神系统和围生期系统等在内的各种生理系统都有不良影响。虽然污染对这些系统的影响已经得到了广泛的研究，但化学污染与免疫之间的复杂关系仍然是一个关键的研究领域。本研究的重点是阐明化学污染与人类免疫之间的关系。为了完成这项任务，本研究进行了全面的综述，包括体外、离体和体内研究，揭示了化学污染影响人类免疫的方式。我们的目的是揭示环境污染物破坏身体防御系统微妙平衡的复杂机制，超越与防御系统的明确关联，深入探讨化学暴露与各种免疫紊乱之间鲜为人知的联系，这增加了我们对潜在机制及其对公共健康影响的理解的紧迫性。
