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CFTR structure: lassoing cystic fibrosis.

作者信息

Ford Bob

机构信息

School of Biological Sciences, The University of Manchester, Manchester, UK.

出版信息

Nat Struct Mol Biol. 2017 Jan 5;24(1):13-14. doi: 10.1038/nsmb.3353.

DOI:10.1038/nsmb.3353
PMID:28054564
Abstract
摘要

相似文献

1
CFTR structure: lassoing cystic fibrosis.囊性纤维化跨膜传导调节因子（CFTR）结构：锁定囊性纤维化
Nat Struct Mol Biol. 2017 Jan 5;24(1):13-14. doi: 10.1038/nsmb.3353.
2
Molecular Genetics of Cystic Fibrosis Transmembrane Conductance Regulator: Genotype and Phenotype.囊性纤维化跨膜传导调节因子的分子遗传学：基因型与表型
Pediatr Clin North Am. 2016 Aug;63(4):585-98. doi: 10.1016/j.pcl.2016.04.002.
3
[Cystic fibrosis transmembrane conductance regulator (CFTR) gene: mutations and clinical phenotypes].[囊性纤维化跨膜传导调节因子（CFTR）基因：突变与临床表型]
Ugeskr Laeger. 2003 Feb 24;165(9):912-6.
4
mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes.代谢型谷氨酸受体 1 与囊性纤维化跨膜电导调节因子相互作用，调节囊性纤维化周围淋巴细胞白细胞介素-10 的分泌。
Mol Immunol. 2012 Jul;51(3-4):310-5. doi: 10.1016/j.molimm.2012.03.029. Epub 2012 Apr 18.
5
F508del-cystic fibrosis transmembrane regulator correctors for treatment of cystic fibrosis: a patent review.用于治疗囊性纤维化的F508del-囊性纤维化跨膜传导调节因子校正剂：专利综述
Expert Opin Ther Pat. 2015;25(9):991-1002. doi: 10.1517/13543776.2015.1045878. Epub 2015 May 15.
6
Genetics of cystic fibrosis: CFTR mutation classifications toward genotype-based CF therapies.囊性纤维化的遗传学：基于基因型的囊性纤维化治疗的CFTR突变分类
Int J Biochem Cell Biol. 2014 Jul;52:94-102. doi: 10.1016/j.biocel.2014.02.023. Epub 2014 Mar 12.
7
Ivacaftor: the first therapy acting on the primary cause of cystic fibrosis.依伐卡托：首个作用于囊性纤维化主要病因的疗法。
Drugs Today (Barc). 2013 Apr;49(4):253-60. doi: 10.1358/dot.2013.49.4.1940984.
8
R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series.三名患有复发性急性胰腺炎和生殖问题的兄弟姐妹中的R248G囊性纤维化跨膜传导调节因子突变：病例系列
J Med Case Rep. 2017 Feb 15;11(1):42. doi: 10.1186/s13256-016-1181-3.
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CFTR structure and cystic fibrosis.囊性纤维化跨膜传导调节因子结构与囊性纤维化
Int J Biochem Cell Biol. 2014 Jul;52:15-25. doi: 10.1016/j.biocel.2014.02.004. Epub 2014 Feb 15.
10
Cystic fibrosis transmembrane conductance regulator channel dysfunction in non-cystic fibrosis bronchiectasis.非囊性纤维化支气管扩张症中囊性纤维化跨膜电导调节子通道功能障碍。
Am J Respir Crit Care Med. 2010 May 15;181(10):1078-84. doi: 10.1164/rccm.200909-1434OC. Epub 2010 Feb 18.

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J Med Chem. 2022 Apr 14;65(7):5212-5243. doi: 10.1021/acs.jmedchem.1c01897. Epub 2022 Apr 4.
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The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations.撒哈拉以南非洲人群中药物代谢动力学（ADME）基因变异的程度及影响
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本文引用的文献

1
Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.囊性纤维化跨膜电导调节子的原子结构。
Cell. 2016 Dec 1;167(6):1586-1597.e9. doi: 10.1016/j.cell.2016.11.014.
2
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.CFTR 氯离子通道的调节区是一个磷酸依赖性的、分子内和分子间相互作用的动态整合器。
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4427-36. doi: 10.1073/pnas.1315104110. Epub 2013 Nov 4.
3
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
哺乳动物和真菌中的多药耐药性——从 MDR 到 PDR：从原子结构到转运机制的艰难历程。
Int J Mol Sci. 2021 Apr 30;22(9):4806. doi: 10.3390/ijms22094806.
4
Ion channels of the lung and their role in disease pathogenesis.肺离子通道及其在疾病发病机制中的作用。
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L859-L872. doi: 10.1152/ajplung.00285.2017. Epub 2017 Oct 12.
囊性纤维化跨膜电导调节因子（CFTR）增效剂 VX-770（ivacaftor）以依赖磷酸化但不依赖 ATP 的方式打开突变 CFTR 的有缺陷的通道门。
J Biol Chem. 2012 Oct 26;287(44):36639-49. doi: 10.1074/jbc.M112.393637. Epub 2012 Aug 31.
4
Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.变构调节平衡热力学稳定性并恢复 ΔF508 CFTR 的功能。
J Mol Biol. 2012 May 25;419(1-2):41-60. doi: 10.1016/j.jmb.2012.03.001. Epub 2012 Mar 8.
5
Syntaxin 16 binds to cystic fibrosis transmembrane conductance regulator and regulates its membrane trafficking in epithelial cells.Syntaxin 16 与囊性纤维化跨膜电导调节因子结合，并调节上皮细胞中其膜运输。
J Biol Chem. 2010 Nov 12;285(46):35519-27. doi: 10.1074/jbc.M110.162438. Epub 2010 Sep 8.
6
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.CFTR增强剂VX-770对体外CF气道上皮细胞功能的挽救作用
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30. doi: 10.1073/pnas.0904709106. Epub 2009 Oct 21.
7
Structure and function of the CFTR chloride channel.囊性纤维化跨膜传导调节因子氯离子通道的结构与功能。
Physiol Rev. 1999 Jan;79(1 Suppl):S23-45. doi: 10.1152/physrev.1999.79.1.S23.
8
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.囊性纤维化基因的鉴定：互补DNA的克隆与特性分析
Science. 1989 Sep 8;245(4922):1066-73. doi: 10.1126/science.2475911.