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胃癌患者术前及术后血浆胃饥饿素水平的预后意义：3年生存研究

Prognostic Significance of Preoperative and Postoperative Plasma Levels of Ghrelin in Gastric Cancer: 3-Year Survival Study.

作者信息

Soleyman-Jahi Saeed, Abdirad Afshin, Fallah Amir Afraz, Ghasemi Sevil, Sadeghi Fatemeh, Heidari Reza, Mahmoodzadeh Habibollah, Zendehdel Kazem

机构信息

Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.

Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

出版信息

Clin Transl Gastroenterol. 2017 Jan 5;8(1):e209. doi: 10.1038/ctg.2016.64.

DOI:10.1038/ctg.2016.64
PMID:28055030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5288598/
Abstract

OBJECTIVES

We aimed to investigate prognostic effects of plasma levels of ghrelin before and after gastrectomy in gastric cancer (GC).

METHODS

We followed 81 GC patients up to 3 years in this study. They were candidates for curative gastrectomy with or without neoadjuvant chemotherapy. Plasma levels of total and active ghrelins before and after the operation were assessed. Association of plasma levels of ghrelin with survival were assessed and adjusted for other potential prognostic factors using Cox regression analyses.

RESULTS

Both total and active ghrelins dropped after gastrectomy (P<0.001 for both). Multiple Cox models revealed worse survival for patients with postoperative total ghrelins below median (hazards ratio (HR)=2.33, 95% confidence interval (CI): 1.01-5.41) or 25th percentile (HR=4.29, 95% CI: 1.48-12.44) compared with patients with higher ghrelin levels. In case of preoperative total ghrelin, patients with either second or third quartiles of plasma ghrelin showed worse survival compared with patients with the lowest quartile (HR=2.67, 95% CI: 1.11-6.38 for second quartile, and HR=2.32, 95% CI: 1.01-5.35 for third quartile vs. the lowest quartile). However, there was no difference between patients with the highest and lowest quartiles (HR=0.78, 95% CI: 0.22-2.73). Similar pattern was observed for preoperative active ghrelin (HR=4.92, 95% CI: 1.80-13.54 for second quartile, and HR=2.87, 95% CI: 1.11-7.38 for third quartile vs. the lowest quartile). Advanced TNM stage (HR=4.88, 95% CI: 1.10-21.77), cachexia (HR=2.99, 95% CI: 1.35-6.63), and receiving no neoadjuvant chemotherapy (HR=2.02, 95% CI: 1.04-3.92) were other poor prognostic factors.

CONCLUSIONS

Preoperative and postoperative plasma levels of ghrelin could predict survival of GC patients with different patterns. This prognostic effect was independent of stage and cachexia. Measurement of plasma ghrelin in GC patients could complement conventional staging for more precise risk-stratification of the patients. Extrinsic admirations of ghrelin after total gastrectomy has potentials to improve survival of GC patients.

摘要

目的

我们旨在研究胃癌（GC）患者胃切除术前和术后血浆胃饥饿素水平的预后影响。

方法

本研究对81例GC患者进行了长达3年的随访。他们是接受或未接受新辅助化疗的根治性胃切除术的候选者。评估了手术前后血浆总胃饥饿素和活性胃饥饿素水平。使用Cox回归分析评估胃饥饿素血浆水平与生存率的关联，并对其他潜在的预后因素进行了调整。

结果

胃切除术后总胃饥饿素和活性胃饥饿素均下降（两者P<0.001）。多个Cox模型显示，术后总胃饥饿素低于中位数的患者生存率较差（风险比（HR）=2.33，95%置信区间（CI）：1.01-5.41）或低于第25百分位数的患者生存率较差（HR=4.29，95%CI：1.48-12.44），与胃饥饿素水平较高的患者相比。对于术前总胃饥饿素，血浆胃饥饿素处于第二或第三四分位数的患者与处于最低四分位数的患者相比，生存率较差（第二四分位数的HR=2.67，95%CI：1.11-6.38，第三四分位数与最低四分位数相比的HR=2.32，95%CI：1.01-5.35）。然而，最高和最低四分位数的患者之间没有差异（HR=0.78，95%CI：0.22-2.73）。术前活性胃饥饿素也观察到类似模式（第二四分位数与最低四分位数相比的HR=4.92，95%CI：1.80-13.54，第三四分位数与最低四分位数相比的HR=2.87，95%CI：1.11-7.38）。晚期TNM分期（HR=4.88，95%CI：1.10-21.77）、恶病质（HR=2.99，95%CI：1.35-6.63）和未接受新辅助化疗（HR=2.02，95%CI：1.04-3.92）是其他不良预后因素。

结论

胃切除术前和术后血浆胃饥饿素水平可以不同模式预测GC患者的生存率。这种预后影响独立于分期和恶病质。测量GC患者的血浆胃饥饿素可以补充传统分期，以便对患者进行更精确的风险分层。全胃切除术后外源性给予胃饥饿素有改善GC患者生存率的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3c/5288598/222cc291fea0/ctg201664f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3c/5288598/222cc291fea0/ctg201664f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3c/5288598/e68373d2caef/ctg201664f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3c/5288598/84d3885ef68a/ctg201664f2.jpg
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本文引用的文献

1
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Drug Chem Toxicol. 2017 Apr;40(2):235-240. doi: 10.1080/01480545.2016.1209678. Epub 2016 Jul 27.
2
Ghrelin administration suppresses inflammation-associated colorectal carcinogenesis in mice.给予胃饥饿素可抑制小鼠炎症相关的结直肠癌发生。
Cancer Sci. 2015 Sep;106(9):1130-6. doi: 10.1111/cas.12725. Epub 2015 Jul 14.
3
Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection.
胃癌手术后体重变化与 2 型糖尿病风险的关系：一项全国性队列研究。
J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):826-834. doi: 10.1002/jcsm.13206. Epub 2023 Mar 2.
4
Objective and Subjective Appetite Assessment in Patients with Gynecological Cancer: A Pre- and Post-Operative Pilot Study.妇科癌症患者的客观和主观食欲评估：一项术前和术后的初步研究。
Int J Environ Res Public Health. 2022 Aug 19;19(16):10322. doi: 10.3390/ijerph191610322.
5
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6
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7
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8
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4
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5
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6
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7
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