Li Sipei, Chung Hee Sung, Simakova Antonina, Wang Zongyu, Park Sangwoo, Fu Liye, Cohen-Karni Devora, Averick Saadyah, Matyjaszewski Krzysztof
Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
Allegheny Health Network - Neuroscience Disruptive Research Lab, 320 East North Avenue, Pittsburgh, Pennsylvania 15212, United States.
Biomacromolecules. 2017 Feb 13;18(2):475-482. doi: 10.1021/acs.biomac.6b01553. Epub 2017 Jan 5.
The synthesis of a sulfoxide-based water-soluble polymer, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), a polymeric analogue of DMSO, by atom transfer radical polymerization (ATRP) is reported. Well-defined linear polymers were synthesized using relatively low amounts of copper catalyst (1000 or 100 ppm). Two types of star polymers were synthesized by either an "arm-first" approach or a "core-first" approach using a biodegradable β-cyclodextrin core. The glass transition temperatures of both the linear polymer (16 °C) and star polymer (32 °C) were determined by differential scanning calorimetry (DSC). The lower critical solution temperature (LCST) of poly(MSEA) was estimated to be ca. 140 °C by extrapolating the LCST of a series of copolymers with NIPAM. Cytotoxicity tests revealed that both the linear and star polymers have low toxicity, even at concentrations up to 3 mg/mL.
报道了通过原子转移自由基聚合（ATRP）合成一种基于亚砜的水溶性聚合物聚（丙烯酸2-（甲基亚磺酰基）乙酯）（聚MSEA），它是二甲基亚砜（DMSO）的聚合物类似物。使用相对少量的铜催化剂（1000 ppm或100 ppm）合成了结构明确的线性聚合物。通过“先臂后核”方法或使用可生物降解的β-环糊精核的“先核后臂”方法合成了两种类型的星形聚合物。通过差示扫描量热法（DSC）测定了线性聚合物（16℃）和星形聚合物（32℃）的玻璃化转变温度。通过外推一系列与NIPAM的共聚物的低临界溶液温度（LCST），估计聚（MSEA）的LCST约为140℃。细胞毒性测试表明，即使在浓度高达3 mg/mL时，线性和星形聚合物都具有低毒性。
