基质金属蛋白酶多重筛查发现，预计会发生先兆子痫的女性尿液中基质金属蛋白酶-2浓度升高。
Matrix metalloproteinase multiplex screening identifies increased MMP-2 urine concentrations in women predicted to develop preeclampsia.
作者信息
Martinez-Fierro Margarita L, Perez-Favila Aurelio, Garza-Veloz Idalia, Espinoza-Juarez Marcela A, Avila-Carrasco Lorena, Delgado-Enciso Ivan, Ortiz-Castro Yolanda, Cardenas-Vargas Edith, Cid-Baez Miguel A, Ramirez-Santoyo Rosa M, Cervantes-Kardasch Victor H, Rodriguez-Sanchez Iram P, Badillo-Almaraz Jose I, Castañeda-Miranda Rodrigo, Solis-Sanchez Luis O, Ortiz-Rodriguez Jose M
机构信息
a Molecular Medicine Laboratory , Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas , Zacatecas , Mexico.
b Centro de Investigacion e Innovacion Tecnologica Industrial, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas , Zacatecas , Mexico.
出版信息
Biomarkers. 2018 Feb;23(1):18-24. doi: 10.1080/1354750X.2017.1279214. Epub 2017 Jan 25.
BACKGROUND
Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia.
OBJECTIVE
The objective of this study is to evaluate the usefulness of nine urinary metalloproteinases to predict the risk of preeclampsia development.
METHODS
MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13 were analyzed in urine (early-pregnancy) from 17 women predicted to develop preeclampsia and 48 controls using the Bio-Plex Pro-Human MMP panel (Bio-Rad, Hercules, CA).
RESULTS
Urinary MMP-2 showed differences between groups which allowed us to calculate an increased risk for PE development of up to 20 times among the study population.
CONCLUSION
Increased urinary concentration of MMP-2 at 12 and 16 weeks of gestation predicted an increased risk of developing preeclampsia in the study population.
背景
子痫前期是一种以高血压和蛋白尿为特征的妊娠疾病，是发展中国家胎儿和孕产妇发病及死亡的主要原因。识别可预测子痫前期的新型准确生物标志物对于改善子痫前期患者的预后至关重要。
目的
本研究的目的是评估九种尿金属蛋白酶预测子痫前期发生风险的效用。
方法
使用Bio-Plex Pro-人类MMP检测板（Bio-Rad，美国加利福尼亚州赫拉克勒斯市）对17名预计会发生子痫前期的女性和48名对照者的尿液（孕早期）中的基质金属蛋白酶-1（MMP-1）、基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-3（MMP-3）、基质金属蛋白酶-7（MMP-7）、基质金属蛋白酶-8（MMP-8）、基质金属蛋白酶-9（MMP-9）、基质金属蛋白酶-10（MMP-10）、基质金属蛋白酶-12（MMP-12）和基质金属蛋白酶-13（MMP-13）进行分析。
结果
尿MMP-2在两组之间存在差异，这使我们能够计算出研究人群中发生子痫前期的风险增加高达20倍。
结论
妊娠12周和16周时尿MMP-2浓度升高预示研究人群发生子痫前期的风险增加。
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