Ravegnini Gloria, Sammarini Giulia, Nannini Margherita, Pantaleo Maria A, Biasco Guido, Hrelia Patrizia, Angelini Sabrina
a Department of Pharmacy and Biotechnology , University of Bologna , Bologna Italy.
b Department of Specialized , Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
Autophagy. 2017 Mar 4;13(3):452-463. doi: 10.1080/15548627.2016.1256522. Epub 2017 Jan 5.
Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and apoptosis play pivotal roles in cancer development. Autophagy plays a key function in maintaining tumor cell survival by providing energy during unfavorable metabolic conditions through its recycling mechanism, and supporting the high energy requirement for metabolism and growth. This review focuses on gastrointestinal stromal tumors and cell death through autophagy and apoptosis, taking into account the involvement of both of these processes in tumor development and growth and as mechanisms of drug resistance. We also focus on the crosstalk between autophagy and apoptosis as an emerging field with major implications for the development of novel therapeutic options.
自噬和凋亡是两种基本的生物学机制，它们可能相互协作或相互拮抗，尽管二者都参与决定细胞在生理或病理条件下的命运。这两种机制在细胞中同时存在，并共享共同的上游信号和刺激。自噬和凋亡在癌症发展中发挥着关键作用。自噬通过其循环机制在不利的代谢条件下提供能量，从而在维持肿瘤细胞存活方面发挥关键作用，并支持肿瘤代谢和生长对高能量的需求。本综述聚焦于胃肠道间质瘤以及通过自噬和凋亡导致的细胞死亡，同时考虑到这两个过程在肿瘤发展和生长中的作用以及作为耐药机制的情况。我们还将自噬与凋亡之间的相互作用作为一个新兴领域进行重点关注，这一领域对新型治疗方案的开发具有重大意义。
