Jia Xi-Bei, Hou Xi-Hua, Ma Qiu-Bo, Cai Xiao-Wen, Li Yi-Ran, Mu Su-Hong, Na Shi-Ping, Xie Ru-Juan, Bao Yu-Shi
1 Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.
Xi-Bei Jia, Xi-Hua Hou and Qiu-Bo Ma are joint first authors.
Angiology. 2017 Oct;68(9):776-781. doi: 10.1177/0003319716686876. Epub 2017 Jan 5.
Chronic kidney disease (CKD) and peripheral arterial disease (PAD) share common risk factors. We assessed renal function and the prevalence of CKD in patients with PAD and investigated the characteristics of the risk factors for CKD in this population. Renal function of 421 patients with PAD was evaluated. Among the participants, 194 (46.1%) patients had decreased estimated glomerular filtration rate (eGFR). The prevalence of CKD was much higher among patients with PAD. Hypertension (odds ratios [ORs] 2.156, 95% confidence interval [CI] 1.413-3.289, P < .001), serum uric acid (OR 3.794, 95% CI 2.220-6.450, P < .001), and dyslipidemia (OR 1.755, 95% CI 1.123-2.745, P = .014) were significantly associated with CKD and the independent risk factors for CKD in patients with PAD. CKD is common and has a high prevalence in a population with PAD. Patients with PAD may be considered as a high-risk population for CKD. Recognition and modification of risk factors for CKD might beneficially decrease CKD incidence and improve prognosis in patients with PAD.
慢性肾脏病（CKD）和外周动脉疾病（PAD）有共同的危险因素。我们评估了PAD患者的肾功能及CKD患病率，并调查了该人群中CKD危险因素的特征。对421例PAD患者的肾功能进行了评估。在参与者中，194例（46.1%）患者的估算肾小球滤过率（eGFR）下降。PAD患者中CKD的患病率要高得多。高血压（比值比[ORs] 2.156，95%置信区间[CI] 1.413 - 3.289，P <.001）、血清尿酸（OR 3.794，95% CI 2.220 - 6.450，P <.001）和血脂异常（OR 1.755，95% CI 1.123 - 2.745，P =.014）与CKD显著相关，且是PAD患者CKD的独立危险因素。CKD在PAD人群中很常见且患病率很高。PAD患者可被视为CKD的高危人群。识别和改变CKD的危险因素可能有助于降低CKD发病率并改善PAD患者的预后。
