Kreilgård B, Hansen J, Fischer T
Pharmacia AS, Herredsvejen 2, Hillerød, Denmark.
Contact Dermatitis. 1989 Jul;21(1):23-7. doi: 10.1111/j.1600-0536.1989.tb04680.x.
The development of the caine mix patch of the TRUE TestTM involved extensive formulation work to obtain optimal release, stability and clinical function. Hydroxypropyl cellulose, ordinarily used in the TRUE TestTM, induced crystallization and inadequate release of benzocaine. Addition of the crystal poison glucose caused rapid degradation of the caines. Polyvinylpyrrolidone (PVP) proved to be a vehicle which incorporated the caines in a stable preparation on the patch. Rapid release of the caines from this vehicle when applied on membranes was confirmed by in vivo patch test studies.
TRUE TestTM 卡因混合贴片的研发涉及大量的制剂工作，以实现最佳释放、稳定性和临床功能。常用于TRUE TestTM的羟丙基纤维素会导致苯佐卡因结晶和释放不足。添加晶体毒物葡萄糖会导致卡因迅速降解。事实证明，聚乙烯吡咯烷酮（PVP）是一种能将卡因稳定地融入贴片制剂的载体。体内贴片试验研究证实，该载体上的卡因应用于膜片时会快速释放。
