Castillo-Juarez Israel, López-Jácome Luis Esaú, Soberón-Chávez Gloria, Tomás María, Lee Jintae, Castañeda-Tamez Paulina, Hernández-Bárragan Iván Ángelo, Cruz-Muñiz Martha Yumiko, Maeda Toshinari, Wood Thomas K, García-Contreras Rodolfo
Department of Microbiology and Parasitology, Faculty of Medicine, UNAM, P.O. Box: 04890, Mexico City, Mexico.
Curr Top Med Chem. 2017 Jan 5.
Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.
铜绿假单胞菌和鲍曼不动杆菌是引起医院感染的两种主要细菌；这两种细菌对几类抗生素都具有耐药性，使得它们引起的感染极难治疗。此外，它们具有形成生物膜的显著能力，这进一步增强了它们的抗微生物耐药性。这两种细菌通过群体感应来协调生物膜的形成和毒力因子的表达，群体感应是一种在高细胞密度下调节基因表达的系统，在细菌感染的发生中起关键作用。因此，干扰这些群体感应系统已被提议作为传统抗生素之外根除细菌感染的一种替代方法。在这篇综述中，我们描述了这两种细菌的群体感应系统、它们协调生物膜形成的方式、群体感应干扰破坏生物膜的最新进展，以及在临床上实施这些新型治疗方案的优点和局限性。
