Dong S Z, Zhu W B
Institute of Medical Biology, Chinese Academy of Medical Scence and Peking Union Medical College, Kunming 650118, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Dec 6;50(12):1032-1035. doi: 10.3760/cma.j.issn.0253-9624.2016.12.003.
Global polio eradication has entered its final phase, but still faces enormous challenges. The Polio Eradication and Endgame Strategic Plan (2013-2018) set the target for making the world polio-free by 2018. Meanwhile, the World Heath Organization Global Action Plan (GAP Ⅲ) recommended that polioviruses be stored under strict conditions after eradication of the wild poliovirus. At least one dose of inactivated poliovirus vaccine (IPV) would be required for each newborn baby in the world to ensure successful completion of the final strategy and GAP Ⅲ. The Sabin IPV has a high production safety and low production cost, compared with the wild-virus IPV and, therefore, can play an important role in the final stage of global polio eradication.
全球消灭脊髓灰质炎已进入最后阶段，但仍面临巨大挑战。《2013 - 2018年消灭脊髓灰质炎及终结战略计划》设定了到2018年使世界无脊髓灰质炎的目标。同时，世界卫生组织全球行动计划（GAPⅢ）建议，在野生脊髓灰质炎病毒被消灭后，脊髓灰质炎病毒应在严格条件下储存。为确保最终战略和GAPⅢ的成功完成，全世界每个新生儿至少需要接种一剂灭活脊髓灰质炎疫苗（IPV）。与野生病毒IPV相比，萨宾IPV具有较高的生产安全性和较低的生产成本，因此可在全球消灭脊髓灰质炎的最后阶段发挥重要作用。
