Cao L M, Zhou Y, Zhang Z, Sun W W, Mu G, Chen W H
Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Dec 6;50(12):1114-1118. doi: 10.3760/cma.j.issn.0253-9624.2016.12.018.
Nowadays, particulate air pollution has been a global environmental problem. Numerous studies has shown that long-term exposure to high level of airborne particulate matter (PM) can damage human health. Respiratory system, as a direct portal to contact with particulate matter, can be more susceptible to airborne particulates. Summarizing latest five-year epidemiological research, the present review is focused on the effects of PM on respiratory system health in different age groups. In detail, we investigated the harmful effect of PM, or its components on three common respiratory diseases, including lung function decline, chronic obstructive pulmonary disease (COPD) and asthma. The result showed that, to a certain degree, PM could induce the decline of lung function, the development and the exacerbation of COPD and asthma by oxidative stress and inflammatory reaction. And it may prompt that exposure to PM can be an improtant risk factor for the respiratory system health.
如今,空气污染颗粒物已成为一个全球性的环境问题。大量研究表明,长期暴露于高水平的空气中颗粒物(PM)会损害人类健康。呼吸系统作为与颗粒物接触的直接门户,更容易受到空气中颗粒物的影响。本综述总结了最近五年的流行病学研究,重点关注PM对不同年龄组呼吸系统健康的影响。具体而言,我们研究了PM或其成分对三种常见呼吸系统疾病的有害影响,包括肺功能下降、慢性阻塞性肺疾病(COPD)和哮喘。结果表明,在一定程度上,PM可通过氧化应激和炎症反应诱导肺功能下降、COPD和哮喘的发生及加重。这可能提示暴露于PM可能是呼吸系统健康的一个重要危险因素。