Heureux N
DIAsource Immunoassays, Louvain-la-Neuve, Belgium.
Adv Clin Chem. 2017;78:59-101. doi: 10.1016/bs.acc.2016.07.002. Epub 2016 Aug 24.
Vitamin D testing is part of laboratory practice since more than 30 years but has become a routine parameter only recently, due to a highly increasing amount of research in the field resulting in new clinical applications. Vitamin D actually represents a family of molecules of which 25OH Vitamin D and 1,25(OH) Vitamin D, under their D3 and D2 forms, are the most important to date. Physical detection methods and immunoassays exist for both molecules and are being reviewed and discussed. New developments in the measurement of C3-epi-25OH Vitamin D, 24,25(OH) Vitamin D, and free/bioavailable 25OH Vitamin D are also presented. The future of Vitamin D testing is considered based on the evolution of laboratories and based on the scientific research that is currently performed.
三十多年来，维生素D检测一直是实验室业务的一部分，但直到最近才成为一项常规指标，这是由于该领域的研究大量增加，产生了新的临床应用。实际上，维生素D代表了一类分子，其中25羟基维生素D和1,25（二羟基）维生素D，以其D3和D2形式，是迄今为止最重要的。针对这两种分子都有物理检测方法和免疫测定法，目前正在对它们进行审查和讨论。还介绍了C3-表-25羟基维生素D、24,25（二羟基）维生素D以及游离/生物可利用的25羟基维生素D测量方面的新进展。基于实验室的发展以及当前正在进行的科学研究，对维生素D检测的未来进行了探讨。
