• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

C3-epi-25(OH)D3 百分比而非水平，可能成为反映多种疾病病理状态下升高的潜在生物标志物：一项横断面病例对照研究。

C3-epi-25(OH)D3 percentage, not level, may be a potential biomarker to reflect its pathological increase in multiple diseases: a cross-sectional case-control study.

机构信息

Department of Laboratory Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, People's Republic of China.

出版信息

Sci Rep. 2023 Dec 27;13(1):23004. doi: 10.1038/s41598-023-50524-3.

DOI:10.1038/s41598-023-50524-3
PMID:38155294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10754939/
Abstract

National surveys in developed countries have examined the presence of C3-epimer of 25-hydroxyvitamin D3 [C3-epi-25(OH)D3]. However, controversy remains regarding its association with disease occurrence due to its high correlation with 25-hydroxyvitamin D3 [25(OH)D3]. This study aims to investigate whether %C3-epi-25(OH)D3 can serve as an indicator for this relationship with various diseases. A total of 3086 healthy participants and 4120 patients were included in this study. We investigated the association between C3-epi-25(OH)D3 and %C3-epi-25(OH)D3 levels with gender, age, and season; compared the performance of C3-epi-25(OH)D3 and %C3-epi-25(OH)D3 across different disease conditions; and explored the correlation between %C3-epi-25(OH)D3 and various diseases. Results indicated that C3-epi-25(OH)D3 varied significantly by gender, age, and season (z/χ2 = 3.765, 10.163, and 150.975, all P < 0.01), while only season for %C3-epi-25(OH)D3 (χ2 = 233.098, P < 0.001). In contrast to the significant decrease in C3-epi-25(OH)D3, %C3-epi-25(OH)D3 showed a significant increase in 8 out of 11 disease categories (z = 3.464 ~ 11.543, all Padj < 0.05). Similar opposite changes were also observed in most of the investigated 32 specific diseases. Moreover, an elevation in %C3-epi-25(OH)D3 was found to be significantly associated with 29 specific diseases both in univariate analysis (OR = 1.16 ~ 2.10, all P < 0.05) and after adjusting for gender, age, and season (OR = 1.15 ~ 1.50, all P < 0.05). However, after further adjustment for 25(OH)D3 levels, the association remained significant only for 15 specific diseases (OR = 1.11 ~ 1.50, all P < 0.05). Seasonal stratification analysis further supports the consistent association of %C3-epi-25(OH)D3 with disease across all or nearly all four seasons. In conclusion, %C3-epi-25(OH)D3 may better reflect the production of C3-epi-25(OH)D3 in disease conditions, thereby offering a more applicable approach to investigate its association with diseases. However, the interpretation of this relationship may be confounded by 25(OH)D3 as a potential covariate.

摘要

本研究旨在探讨 C3-epi-25(OH)D3 是否可以作为与各种疾病相关的指标。研究共纳入 3086 名健康参与者和 4120 名患者。我们研究了 C3-epi-25(OH)D3 和%C3-epi-25(OH)D3 水平与性别、年龄和季节之间的关系；比较了 C3-epi-25(OH)D3 和%C3-epi-25(OH)D3 在不同疾病状态下的表现；并探讨了%C3-epi-25(OH)D3 与各种疾病之间的相关性。结果表明，C3-epi-25(OH)D3 存在显著的性别、年龄和季节差异（z/χ2=3.765、10.163 和 150.975，均 P<0.01），而%C3-epi-25(OH)D3 仅存在季节差异（χ2=233.098，P<0.001）。与 C3-epi-25(OH)D3 的显著下降相反，8 种疾病类别中的%C3-epi-25(OH)D3 显著增加（z=3.46411.543，均 Padj<0.05）。在大多数研究的 32 种特定疾病中也观察到类似的相反变化。此外，在单因素分析（OR=1.162.10，均 P<0.05）和调整性别、年龄和季节后（OR=1.151.50，均 P<0.05），发现%C3-epi-25(OH)D3 升高与 29 种特定疾病显著相关。然而，在进一步调整 25(OH)D3 水平后，这种关联仅在 15 种特定疾病中仍然显著（OR=1.111.50，均 P<0.05）。季节分层分析进一步支持%C3-epi-25(OH)D3 在所有或几乎所有四个季节与疾病的一致相关性。总之，%C3-epi-25(OH)D3 可能更好地反映疾病状态下 C3-epi-25(OH)D3 的产生，从而提供一种更适用的方法来研究其与疾病的关系。然而，这种关系的解释可能受到 25(OH)D3 作为潜在混杂因素的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/90339df85a3d/41598_2023_50524_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/2898ae0761b6/41598_2023_50524_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/a5b41abb0f7a/41598_2023_50524_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/90339df85a3d/41598_2023_50524_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/2898ae0761b6/41598_2023_50524_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/a5b41abb0f7a/41598_2023_50524_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f8/10754939/90339df85a3d/41598_2023_50524_Fig3_HTML.jpg

相似文献

1
C3-epi-25(OH)D3 percentage, not level, may be a potential biomarker to reflect its pathological increase in multiple diseases: a cross-sectional case-control study.C3-epi-25(OH)D3 百分比而非水平，可能成为反映多种疾病病理状态下升高的潜在生物标志物：一项横断面病例对照研究。
Sci Rep. 2023 Dec 27;13(1):23004. doi: 10.1038/s41598-023-50524-3.
2
Differential performance regarding the relationship of C3-epi-25(OH)D3 levels and %C3-epi-25(OH)D3 with common pediatric diseases: a case control study.关于 C3-epi-25(OH)D3 水平与%C3-epi-25(OH)D3 与常见儿科疾病关系的差异表现：一项病例对照研究。
BMC Pediatr. 2024 Sep 13;24(1):577. doi: 10.1186/s12887-024-05072-8.
3
C3-Epimer of 25-Hydroxyvitamin D3 as a Superior Marker for Predicting the Severity of Chronic Kidney Disease in Rheumatoid Arthritis Patients.25-羟基维生素 D3 的 C3-Epimer 作为预测类风湿关节炎患者慢性肾脏病严重程度的更优标志物。
Oxid Med Cell Longev. 2022 Apr 22;2022:5268706. doi: 10.1155/2022/5268706. eCollection 2022.
4
National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry in the US Population during 2007-2010.2007 - 2010年美国人群中通过液相色谱 - 串联质谱法测定的血清总25 - 羟基维生素D及代谢物浓度的全国估计值。
J Nutr. 2016 May;146(5):1051-61. doi: 10.3945/jn.115.227728. Epub 2016 Apr 6.
5
Vitamin D Status in Children With Short Stature: Accurate Determination of Serum Vitamin D Components Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.采用高效液相色谱-串联质谱法准确测定身材矮小儿童血清维生素 D 成分的维生素 D 状态。
Front Endocrinol (Lausanne). 2021 Oct 13;12:707283. doi: 10.3389/fendo.2021.707283. eCollection 2021.
6
Serum C3 epimer of 25-hydroxyvitamin D and its determinants in adults: a national health examination survey in Thais.成人血清25-羟基维生素D的C3差向异构体及其决定因素：泰国全国健康检查调查
Osteoporos Int. 2015 Sep;26(9):2339-44. doi: 10.1007/s00198-015-3125-y. Epub 2015 Apr 14.
7
Epidemiologic study of the C-3 epimer of 25-hydroxyvitamin D(3) in a population-based sample.基于人群样本的维生素 D（3）C-3 差向异构体的流行病学研究。
Clin Nutr. 2014 Jun;33(3):421-5. doi: 10.1016/j.clnu.2013.06.005. Epub 2013 Jun 21.
8
C3-epimerization of 25-hydroxyvitamin D increases with increasing serum 25-hydroxyvitamin D levels and shows a high degree of tracking over time.25-羟基维生素D的C3-差向异构化随着血清25-羟基维生素D水平的升高而增加，并且随时间显示出高度的跟踪性。
Clin Biochem. 2018 Apr;54:61-67. doi: 10.1016/j.clinbiochem.2018.02.013. Epub 2018 Feb 21.
9
Evaluation of vitamin D storage in patients with chronic kidney disease: Detection of serum vitamin D metabolites using high performance liquid chromatography-tandem mass spectrometry.采用高效液相色谱-串联质谱法检测血清维生素 D 代谢物评价慢性肾脏病患者维生素 D 储存情况。
J Steroid Biochem Mol Biol. 2021 Jun;210:105860. doi: 10.1016/j.jsbmb.2021.105860. Epub 2021 Mar 1.
10
Vitamin D C3-epimer levels are proportionally higher with oral vitamin D supplementation compared to ultraviolet irradiation of skin in mice but not humans.与皮肤紫外线照射相比，口服维生素 D 补充剂可使维生素 D C3-差向异构体水平成比例升高，但这种情况仅见于小鼠，而不适用于人类。
J Steroid Biochem Mol Biol. 2019 Feb;186:110-116. doi: 10.1016/j.jsbmb.2018.10.002. Epub 2018 Oct 5.

引用本文的文献

1
Exploration of vitamin D hydroxy metabolites C3 epimers in patients with cardiovascular disease: an observational study.心血管疾病患者维生素D羟基代谢物C3差向异构体的探索：一项观察性研究。
Biosci Rep. 2025 Jan 27;45(2):BSR20241558. doi: 10.1042/BSR20241558.
2
High ratio of epi-25-(OH)-vitamin D3 to 25-(OH)-vitamin D3 increases the risk of asthma attack in American asthma adults: a population study.高比例的表-25-(OH)-维生素 D3 与 25-(OH)-维生素 D3 增加美国成年哮喘患者哮喘发作的风险：一项人群研究。
BMC Public Health. 2024 Sep 30;24(1):2670. doi: 10.1186/s12889-024-20185-6.

本文引用的文献

1
C3-Epimer of 25-Hydroxyvitamin D3 as a Superior Marker for Predicting the Severity of Chronic Kidney Disease in Rheumatoid Arthritis Patients.25-羟基维生素 D3 的 C3-Epimer 作为预测类风湿关节炎患者慢性肾脏病严重程度的更优标志物。
Oxid Med Cell Longev. 2022 Apr 22;2022:5268706. doi: 10.1155/2022/5268706. eCollection 2022.
2
Vitamin D and Phosphate Interactions in Health and Disease.维生素 D 与磷在健康与疾病中的相互作用。
Adv Exp Med Biol. 2022;1362:37-46. doi: 10.1007/978-3-030-91623-7_5.
3
Vitamin D metabolites and risk of first clinical diagnosis of central nervous system demyelination.
维生素D代谢物与中枢神经系统脱髓鞘首次临床诊断风险
J Steroid Biochem Mol Biol. 2022 Apr;218:106060. doi: 10.1016/j.jsbmb.2022.106060. Epub 2022 Jan 11.
4
Interlaboratory comparison of 25-hydroxyvitamin D assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2 - Part 1 liquid chromatography - tandem mass spectrometry (LC-MS/MS) assays - impact of 3-epi-25-hydroxyvitamin D on assay performance.25-羟基维生素D检测方法的实验室间比对：维生素D标准化计划（VDSP）比对研究2 - 第1部分液相色谱 - 串联质谱（LC-MS/MS）检测方法 - 3-表-25-羟基维生素D对检测性能的影响
Anal Bioanal Chem. 2022 Jan;414(1):333-349. doi: 10.1007/s00216-021-03576-1. Epub 2021 Aug 25.
5
Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients.维生素 D 代谢物与住院 COVID-19 患者的临床结局。
Nutrients. 2021 Jun 22;13(7):2129. doi: 10.3390/nu13072129.
6
Evaluation of vitamin D storage in patients with chronic kidney disease: Detection of serum vitamin D metabolites using high performance liquid chromatography-tandem mass spectrometry.采用高效液相色谱-串联质谱法检测血清维生素 D 代谢物评价慢性肾脏病患者维生素 D 储存情况。
J Steroid Biochem Mol Biol. 2021 Jun;210:105860. doi: 10.1016/j.jsbmb.2021.105860. Epub 2021 Mar 1.
7
Vitamin D metabolite ratio as an indicator of vitamin D status and its association with diabetes complications.维生素 D 代谢产物比值作为维生素 D 状态的指标及其与糖尿病并发症的关系。
BMC Endocr Disord. 2020 Oct 27;20(1):161. doi: 10.1186/s12902-020-00641-1.
8
ICD-11 vs. ICD-10 - a review of updates and novelties introduced in the latest version of the WHO International Classification of Diseases.ICD-11 与 ICD-10 的比较——世卫组织国际疾病分类最新版本中引入的更新和创新回顾。
Psychiatr Pol. 2020 Feb 29;54(1):7-20. doi: 10.12740/PP/103876.
9
Vitamin D status is seasonally stable in northern European dogs.北欧犬的维生素 D 状态具有季节性稳定性。
Vet Clin Pathol. 2020 Jun;49(2):279-291. doi: 10.1111/vcp.12859. Epub 2020 May 20.
10
Epimers of Vitamin D: A Review.维生素 D 差向异构体：综述。
Int J Mol Sci. 2020 Jan 11;21(2):470. doi: 10.3390/ijms21020470.