Kreipke R E, Kwon Y V, Shcherbata H R, Ruohola-Baker H
University of Washington, School of Medicine, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, United States.
University of Washington, School of Medicine, Seattle, WA, United States.
Curr Top Dev Biol. 2017;121:83-109. doi: 10.1016/bs.ctdb.2016.07.003. Epub 2016 Aug 5.
Drosophila melanogaster provides a powerful platform with which researchers can dissect complex genetic questions and biochemical pathways relevant to a vast array of human diseases and disorders. Of particular interest, much work has been done with flies to elucidate the molecular mechanisms underlying muscle degeneration diseases. The fly is particularly useful for modeling muscle degeneration disorders because there are no identified satellite muscle cells to repair adult muscle following injury. This allows for the identification of endogenous processes of muscle degeneration as discrete events, distinguishable from phenotypes due to the lack of stem cell-based regeneration. In this review, we will discuss the ways in which the fruit fly provides a powerful platform with which to study human muscle degeneration disorders.
黑腹果蝇为研究人员提供了一个强大的平台，借此他们能够剖析与大量人类疾病和病症相关的复杂遗传问题及生化途径。特别值得关注的是，针对果蝇展开了诸多研究工作，以阐明肌肉退行性疾病背后的分子机制。果蝇对于模拟肌肉退行性疾病尤为有用，因为在损伤后没有已确定的卫星肌细胞来修复成年肌肉。这使得能够将肌肉退行性变的内源性过程识别为离散事件，与因缺乏基于干细胞的再生而产生的表型区分开来。在这篇综述中，我们将探讨果蝇为研究人类肌肉退行性疾病提供强大平台的方式。
