Teixeira Sara Reis, Elias Paula Condé Lamparelli, Leite Andrea Farias de Melo, de Oliveira Tatiane Mendes Gonçalves, Muglia Valdair Francisco, Elias Junior Jorge
MD, PhD, Attending Physician at the Centro de Ciências das Imagens e Física Médica (CCIFM), Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil.
MD, PhD, Endocrinology Division of the Department of Internal Medicine, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil.
Radiol Bras. 2016 Nov-Dec;49(6):363-368. doi: 10.1590/0100-3984.2015.0045.
To assess the feasibility and reliability of apparent diffusion coefficient (ADC) measurements of normal adrenal glands.
This was a retrospective study involving 32 healthy subjects, divided into two groups: prepubertal (PreP, = 12), aged from 2 months to 12.5 years (4 males; 8 females); and postpubertal (PostP, = 20), aged from 11.9 to 61 years (5 males; 15 females). Diffusion-weighted magnetic resonance imaging (DW-MRI) sequences were acquired at a 1.5 T scanner using values of 0, 20, 500, and 1000 s/mm. Two radiologists evaluated the images. ADC values were measured pixel-by-pixel on DW-MRI scans, and automatic co-registration with the ADC map was obtained.
Mean ADC values for the right adrenal glands were 1.44 × 10 mm/s for the PreP group and 1.23 × 10 mm/s for the PostP group, whereas they were 1.58 × 10 mm/s and 1.32 × 10 mm/s, respectively, for the left glands. ADC values were higher in the PreP group than in the PostP group ( < 0.05). Agreement between readers was almost perfect (intraclass correlation coefficient, 0.84-0.94; < 0.05).
Our results demonstrate the feasibility and reliability of performing DW-MRI measurements of normal adrenal glands. They could also support the feasibility of ADC measurements of small structures.
评估正常肾上腺表观扩散系数（ADC）测量的可行性和可靠性。
这是一项回顾性研究，纳入32名健康受试者，分为两组：青春期前组（PreP，n = 12），年龄从2个月至12.5岁（4名男性；8名女性）；青春期后组（PostP，n = 20），年龄从11.9至61岁（5名男性；15名女性）。在1.5 T扫描仪上采用0、20、500和1000 s/mm²的b值获取扩散加权磁共振成像（DW-MRI）序列。两名放射科医生对图像进行评估。在DW-MRI扫描上逐像素测量ADC值，并获得与ADC图的自动配准。
PreP组右侧肾上腺的平均ADC值为1.44×10⁻³ mm²/s，PostP组为1.23×10⁻³ mm²/s，而左侧肾上腺分别为1.58×10⁻³ mm²/s和1.32×10⁻³ mm²/s。PreP组的ADC值高于PostP组（P < 0.05）。阅片者之间的一致性几乎完美（组内相关系数，0.84 - 0.94；P < 0.05）。
我们的结果证明了对正常肾上腺进行DW-MRI测量的可行性和可靠性。它们也支持对小结构进行ADC测量的可行性。
