Wang Hai-Yi, Wang Jia, Tang Ye-Huan, Ye Hui-Yi, Ma Lin
Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Chin Med J (Engl). 2015 Feb 20;128(4):499-503. doi: 10.4103/0366-6999.151103.
Coronal diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values have gradually become applied (following conventional axial DW-MRI) in the renal analysis. To explore whether data obtained using coronal DW-MRI are comparable with those derived using axial DW-MRI, this preliminary study sought to assess the agreement in renal ADC values between coronal DW-MRI and axial DW-MRI.
Thirty-four healthy volunteers were enrolled in the study; written consents were obtained. All subjects underwent respiratory-triggered axial and coronal DW-MRI using a 1.5-MR system with b values of 0 and 800 s/mm 2 . The signal-to-noise ratios (SNRs) of the two DW-MRI sequences were measured and statistically compared using the paired t-test. The extent of agreement of ADC values of the upper pole, mid-pole, and lower pole of the kidney; the mean ADC values of the left kidney and right kidney; and the mean ADC values of the bilateral kidneys were evaluated via calculation of intraclass correlation coefficients (ICCs) or Bland-Altman method between the two DW-MRI sequences.
The SNR of coronal DW-MR images was statistically inferior to that of axial DW-MR images (P < 0.001). The ICCs of the ADC values of each region of interest, and the mean ADC values of bilateral kidneys, between the two sequences, were greater than 0.5, and the mean ADCs of the bilateral kidneys demonstrated the highest ICC (0.869; 95% confidence interval: 0.739-0.935). In addition, 94.1% (32/34), 94.1% (32/34), and 97.1% (31/34) of the ADC bias was inside the limits of agreement in terms of the mean ADC values of the left kidneys, right kidneys, and bilateral kidneys when coronal and axial DWI-MRI were compared.
ADC values derived using coronal DW-MRI exhibited moderate-to-good agreement to those of axial DW-MRI, rendering the former an additional useful DW-MRI method, and causing the ADC values derived using the two types of DW-MRI to be comparable.
冠状位扩散加权磁共振成像（DW-MRI）及表观扩散系数（ADC）值已逐渐（继传统轴位DW-MRI之后）应用于肾脏分析。为探究冠状位DW-MRI所获数据是否与轴位DW-MRI所获数据具有可比性，本初步研究旨在评估冠状位DW-MRI与轴位DW-MRI之间肾脏ADC值的一致性。
34名健康志愿者纳入本研究；获取书面知情同意书。所有受试者使用b值为0和800 s/mm²的1.5-MR系统接受呼吸触发的轴位和冠状位DW-MRI检查。测量两个DW-MRI序列的信噪比（SNR），并采用配对t检验进行统计学比较。通过计算两个DW-MRI序列之间的组内相关系数（ICC）或Bland-Altman方法，评估肾脏上极、中极和下极ADC值的一致性程度；左肾和右肾的平均ADC值；以及双侧肾脏的平均ADC值。
冠状位DW-MR图像的SNR在统计学上低于轴位DW-MR图像（P < 0.001）。两个序列之间各感兴趣区域的ADC值以及双侧肾脏的平均ADC值的ICC均大于0.5，双侧肾脏的平均ADC显示出最高的ICC（0.869；95%置信区间：0.739 - 0.935）。此外，当比较冠状位和轴位DWI-MRI时，就左肾、右肾和双侧肾脏的平均ADC值而言，94.1%（32/34）、94.1%（32/34）和97.1%（31/34）的ADC偏差在一致性界限内。
冠状位DW-MRI得出的ADC值与轴位DW-MRI得出的ADC值表现出中度到良好的一致性，使前者成为另一种有用的DW-MRI方法，并使得两种类型的DW-MRI得出的ADC值具有可比性。
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