Alagöz Neşe, Alagöz Cengiz, Yıldırım Yusuf, Yeşilkaya Ceren, Altan Çiğdem, Bozkurt Ercüment, Şatana Banu, Başarır Berna, Taşkapılı Muhittin
Beyoğlu Eye Training and Research Hospital, İstanbul, Turkey.
Turk J Ophthalmol. 2016 Aug;46(4):169-174. doi: 10.4274/tjo.88785. Epub 2016 Aug 15.
To evaluate the effect of adjuvant intracameral triamcinolone acetonide (TA) on the surgical results of trabeculectomy with mitomycin C.
All consecutive trabeculectomy cases performed in the glaucoma clinic between July 2012 and December 2013 were retrospectively reviewed from the patient charts. Only those with follow-up of 12 months or longer were included. Patients with intraoperative intracameral TA (study group, n=19) were compared to those without TA (control group, n=21) in terms of surgical success, intraocular pressure (IOP) change, medication use and complications.
Forty eyes of 31 patients (21 male/10 female, mean age 64.2±13.8 years) were included in the study. The mean follow-up period was 20.9±5.1 months and 20.7±6.7 months in the study and control groups, respectively (p=0.830). Baseline IOP was 26.4±9.9 and 25.2±7.6 mmHg (p=0.979), and final IOP was 12.7±2.6 and 13.6±3 mmHg in both groups respectively (p=0.226). At the final follow-up, complete success was observed in 68.4% and 52.4% of the study and control groups (p=0.349) and anti-glaucoma medication was used by 31.6% (mean number of medications: 0.79±1.2) and 47.6% (mean number of medications: 1.33±1.7), respectively (p>0.05). Bleb encapsulation, leakage, suture-lysis and hypotony rates were similar in both groups (for all, p>0.05). Cataract progression was noted in six (35.3%) and in five (26.3%) of the phakic eyes in the study and control groups, respectively (p=0.720).
When used intracamerally, TA did not increase the complication rate in trabeculectomy surgery. Although the group that received TA showed lower IOP levels, use of fewer medications and fewer eyes requiring medication, the differences did not reach significance.
评估辅助性前房内注射曲安奈德（TA）对丝裂霉素C小梁切除术手术效果的影响。
回顾性分析2012年7月至2013年12月在青光眼门诊连续进行的小梁切除术病例的患者病历。仅纳入随访时间为12个月或更长时间的患者。将术中前房内注射TA的患者（研究组，n = 19）与未注射TA的患者（对照组，n = 21）在手术成功率、眼压（IOP）变化、药物使用和并发症方面进行比较。
31例患者（21例男性/10例女性，平均年龄64.2±13.8岁）的40只眼纳入研究。研究组和对照组的平均随访时间分别为20.9±5.1个月和20.7±6.7个月（p = 0.830）。两组的基线眼压分别为26.4±9.9和25.2±7.6 mmHg（p = 0.979），最终眼压分别为12.7±2.6和13.6±3 mmHg（p = 0.226）。在最后一次随访时，研究组和对照组分别有68.4%和52.4%的患者获得完全成功（p = 0.349），分别有31.6%（平均用药数量：0.79±1.2）和47.6%（平均用药数量：1.33±1.7）的患者使用抗青光眼药物（p>0.05）。两组的滤过泡包裹、渗漏、缝线溶解和低眼压发生率相似（所有p>0.05）。研究组和对照组分别有6只（35.3%）和5只（26.3%）有晶状体眼出现白内障进展（p = 0.720）。
前房内使用TA不会增加小梁切除术的并发症发生率。虽然接受TA的组眼压水平较低、使用药物较少且需要用药的眼数较少，但差异无统计学意义。
