Abbas Fedaey Mohammed, Julie Bridson M, Sharma Ajay, Halawa Ahmed
Fedaey Mohammed Abbas, Nephrology Department, Jaber El Ahmed Military Hospital, Safat 13005, Kuwait.
World J Transplant. 2016 Dec 24;6(4):682-688. doi: 10.5500/wjt.v6.i4.682.
The risk of contrast-induced nephropathy (CIN) in renal transplant recipients is increased in diabetics, patients with impaired basal kidney function, patients in shock, patients presenting with acute emergency and in old age recipients. Approximately one-third of all hospitalized patients with acute kidney injury is attributed to CIN. In the United States, it is the third leading cause of hospital-acquired renal failure. Therefore, efforts should be directed to minimize CIN-related morbidity and mortality as well as to shorten hospital stay. While the role of peri-procedural prophylactic hydration with saline is unequivocal; the use of acetyl cysteine is not based on robust evidence. The utility of theophylline, aminophylline, calcium channel blockers, natriuretic peptide, and diuretics does not have proven role in attenuating CIN incidence. We aim to analyze the evidence for using various protocols in published literature to limit CIN-associated morbidity and mortality, particularly during surveillance of the renal allograft survival.
糖尿病患者、基础肾功能受损患者、休克患者、急性急症患者以及老年肾移植受者发生对比剂肾病（CIN）的风险会增加。所有急性肾损伤住院患者中约三分之一归因于CIN。在美国，它是医院获得性肾衰竭的第三大主要原因。因此，应努力将与CIN相关的发病率和死亡率降至最低，并缩短住院时间。虽然围手术期用生理盐水进行预防性水化的作用是明确的；但使用乙酰半胱氨酸并非基于有力证据。茶碱、氨茶碱、钙通道阻滞剂、利钠肽和利尿剂在降低CIN发生率方面尚未证实有作用。我们旨在分析已发表文献中使用各种方案限制CIN相关发病率和死亡率的证据，特别是在监测肾移植存活期间。
