特刊：新型抗真菌药物的发现
Special Issue: Novel Antifungal Drug Discovery.
作者信息
Del Poeta Maurizio
机构信息
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA;
出版信息
J Fungi (Basel). 2016 Dec;2(4). doi: 10.3390/jof2040033. Epub 2016 Dec 14.
Abstract
This Special Issue is designed to highlight the latest research and development on new antifungal compounds with mechanisms of action different from the ones of polyenes, azoles, and echinocandins. The papers presented here highlight new pathways and targets that could be exploited for the future development of new antifungal agents to be used alone or in combination with existing antifungals. A computational model for better predicting antifungal drug resistance is also presented.
摘要
本期特刊旨在突出新型抗真菌化合物的最新研究与开发成果，这些化合物的作用机制有别于多烯类、唑类和棘白菌素类。此处发表的论文突出了一些新途径和靶点，这些可用于未来单独或与现有抗真菌药物联合使用的新型抗真菌药物的开发。还介绍了一个用于更好地预测抗真菌药物耐药性的计算模型。
相似文献
1
Special Issue: Novel Antifungal Drug Discovery.特刊：新型抗真菌药物的发现
J Fungi (Basel). 2016 Dec;2(4). doi: 10.3390/jof2040033. Epub 2016 Dec 14.
2
Antifungals discovery: an insight into new strategies to combat antifungal resistance.抗真菌药物的发现：对抗真菌耐药性新策略的洞察
Lett Appl Microbiol. 2018 Jan;66(1):2-13. doi: 10.1111/lam.12820. Epub 2017 Dec 11.
3
Antifungals: Mechanism of Action and Drug Resistance.抗真菌药物：作用机制与耐药性
Adv Exp Med Biol. 2016;892:327-349. doi: 10.1007/978-3-319-25304-6_14.
4
Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy.当前的抗真菌药物、新前景及抗真菌治疗的未来方法
Antibiotics (Basel). 2020 Jul 25;9(8):445. doi: 10.3390/antibiotics9080445.
5
New antifungal agents.新型抗真菌药物。
Dermatol Clin. 2003 Jul;21(3):565-76. doi: 10.1016/s0733-8635(03)00024-x.
6
Antifungal therapeutics for dimorphic fungal pathogens.用于双相真菌病原体的抗真菌治疗药物。
Virulence. 2017 Feb 17;8(2):211-221. doi: 10.1080/21505594.2016.1235653. Epub 2016 Sep 19.
7
Antifungals.抗真菌药。
Biochem Pharmacol. 2017 Jun 1;133:86-96. doi: 10.1016/j.bcp.2016.11.019. Epub 2016 Nov 21.
8
Elucidating drug resistance in human fungal pathogens.阐明人类真菌病原体的耐药性。
Future Microbiol. 2014;9(4):523-42. doi: 10.2217/fmb.14.18.
9
Microbial natural products as a source of antifungals.作为抗真菌剂来源的微生物天然产物
Clin Microbiol Infect. 2003 Jan;9(1):15-32. doi: 10.1046/j.1469-0691.2003.00489.x.
10
Antifungals: mechanism of action and resistance, established and novel drugs.抗真菌药物：作用机制与耐药性，已上市及新型药物
Curr Opin Microbiol. 1998 Oct;1(5):547-57. doi: 10.1016/s1369-5274(98)80087-8.
引用本文的文献
1
Genotypic Analysis of Candida tropicalis Clinical Isolates From Korea via Multilocus Sequence Typing.通过多位点序列分型对来自韩国的热带念珠菌临床分离株进行基因分型分析。
Microbiologyopen. 2025 Aug;14(4):e70024. doi: 10.1002/mbo3.70024.
2
Multilocus Sequence Typing Reveals a New Cluster of Closely Related Genotypes in Italian Patients With Neurological Disorders.多位点序列分型揭示了意大利神经系统疾病患者中一组新的密切相关基因型。
Front Microbiol. 2018 Apr 6;9:679. doi: 10.3389/fmicb.2018.00679. eCollection 2018.
3
Non-invasive and invasive diagnoses of aspergillosis in a rat model by mass spectrometry.通过质谱法对大鼠模型中的侵袭性和非侵袭性曲霉病进行诊断。
Sci Rep. 2017 Nov 28;7(1):16523. doi: 10.1038/s41598-017-16648-z.
本文引用的文献
1
Virulence Factors as Targets for Anticryptococcal Therapy.作为抗隐球菌治疗靶点的毒力因子
J Fungi (Basel). 2016 Nov 30;2(4):29. doi: 10.3390/jof2040029.
2
New Horizons in Antifungal Therapy.抗真菌治疗的新视野
J Fungi (Basel). 2016 Oct 2;2(4):26. doi: 10.3390/jof2040026.
3
Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery.肌醇多磷酸激酶、真菌致病性与药物发现
J Fungi (Basel). 2016 Sep 6;2(3):24. doi: 10.3390/jof2030024.
4
A Quantitative Model to Estimate Drug Resistance in Pathogens.一种估计病原体耐药性的定量模型。
J Fungi (Basel). 2016 Dec;2(4). doi: 10.3390/jof2040030. Epub 2016 Dec 5.
5
Intracellular concentrations of anidulafungin in different compartments of the peripheral blood.外周血不同部位中阿尼芬净的细胞内浓度。
Int J Antimicrob Agents. 2013 Apr;41(4):379-82. doi: 10.1016/j.ijantimicag.2012.12.002. Epub 2013 Jan 12.
6
Overview of invasive fungal infections.侵袭性真菌感染概述。
Methods Mol Biol. 2013;968:1-23. doi: 10.1007/978-1-62703-257-5_1.
7
Hidden killers: human fungal infections.隐形杀手：人类真菌感染。
Sci Transl Med. 2012 Dec 19;4(165):165rv13. doi: 10.1126/scitranslmed.3004404.
8
Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome.分析卡氏肺孢子虫基因组内的现有抗真菌药物及其靶标。
Curr Drug Targets. 2012 Nov;13(12):1575-85. doi: 10.2174/138945012803530107.
9
Echinocandins: are they all the same?棘白菌素类药物：它们都一样吗？
J Chemother. 2011 Dec;23(6):319-25. doi: 10.1179/joc.2011.23.6.319.
10
Intracellular concentrations of micafungin in different cellular compartments of the peripheral blood.不同细胞区室内米卡芬净在患者外周血中的细胞内浓度。
Int J Antimicrob Agents. 2012 Mar;39(3):228-31. doi: 10.1016/j.ijantimicag.2011.11.006. Epub 2012 Jan 9.
Zotero 插件