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内皮细胞的酶促抗氧化系统。

Enzymatic antioxidant system of endotheliocytes.

作者信息

Sharapov M G, Goncharov R G, Gordeeva A E, Novoselov V I, Antonova O A, Tikhaze A K, Lankin V Z

机构信息

Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.

Russian Cardiology Research and Production Center, Russian Federation Ministry of Health, 3ya Cherepkovskaya ul. 15A, Moscow, 121552, Russia.

出版信息

Dokl Biochem Biophys. 2016 Nov;471(1):410-412. doi: 10.1134/S1607672916060090. Epub 2017 Jan 6.

DOI:10.1134/S1607672916060090
PMID:28058676
Abstract

It is shown that endothelial cells from human umbilical vein have a reduced activity and gene expression of the "classic" antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase, and Se-containing glutathione peroxidase). At the same time, a high expression level of peroxiredoxin genes was identified in the same endothelial cells, which obviously indicates the predominant involvement of these enzymes in protecting the endothelium from the damaging effect of free radical peroxidation.

摘要

研究表明，人脐静脉内皮细胞中“经典”抗氧化酶（铜锌超氧化物歧化酶、过氧化氢酶和含硒谷胱甘肽过氧化物酶）的活性和基因表达降低。同时，在相同的内皮细胞中发现过氧化物酶基因的高表达水平，这明显表明这些酶在保护内皮免受自由基过氧化损伤作用中起主要作用。

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