一种用于在活细胞中选择性检测谷胱甘肽的线粒体靶向荧光探针。
A mitochondria-targeting fluorescent probe for the selective detection of glutathione in living cells.
作者信息
Liu Xue-Liang, Niu Li-Ya, Chen Yu-Zhe, Zheng Mei-Ling, Yang Yunxu, Yang Qing-Zheng
机构信息
School of Chemistry and biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China.
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.
出版信息
Org Biomol Chem. 2017 Feb 1;15(5):1072-1075. doi: 10.1039/c6ob02407f.
We report a fluorescent probe for the selective detection of mitochondrial glutathione (GSH). The probe, containing triphenylphosphine as a mitochondrial targeting group, exhibited ratiometric and selective detection of GSH over Cys/Hcy. The probe was used for imaging mitochondrial GSH in living HeLa cells.
我们报道了一种用于选择性检测线粒体谷胱甘肽（GSH）的荧光探针。该探针含有三苯基膦作为线粒体靶向基团，对GSH的检测具有比率型且对Cys/Hcy具有选择性。该探针用于活的HeLa细胞中线粒体GSH的成像。
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