染色质机制中的表观遗传修饰及其在小儿脑肿瘤中的失调：对表观遗传治疗的见解。
Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.
作者信息
Maury Eleonore, Hashizume Rintaro
机构信息
a Department of Neurological Surgery , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
b Science in Society , Northwestern University , Evanston , IL , USA.
出版信息
Epigenetics. 2017 May 4;12(5):353-369. doi: 10.1080/15592294.2016.1278095. Epub 2017 Jan 6.
Abstract
Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.
摘要
恶性肿瘤的特征是表观遗传模式的重编程。这种重编程包括DNA甲基化的增加或减少以及共价组蛋白修饰正常模式的破坏，这与染色质重塑过程的变化相关。本综述将聚焦于这种重编程背后的机制，特别是组蛋白修饰在染色质机制中的作用以及脑癌中发生的表观遗传过程的修饰，特别关注小儿脑肿瘤的表观遗传疗法。
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