Sridhar Mittanamalli S
Department of Ophthalmology, Krishna Institute of Medical Sciences, Hyderabad, India.
Cornea. 2017 Mar;36(3):343-346. doi: 10.1097/ICO.0000000000001126.
To present anterior segment optical coherence tomography (AS-OCT) findings of the Kayser-Fleischer (KF) ring in Wilson disease (WD) and to discuss the potential advantages of evaluating the KF ring by AS-OCT.
This is a retrospective case series of 7 patients with WD with KF rings seen in our institute during the study period (August 2015 to June 2016). All patients underwent slit-lamp examination of the cornea and AS-OCT (Optovue RTVue Premier). In 2 patients, the length of the KF ring was measured using the gray scale of AS-OCT.
The KF ring on the gray scale of AS-OCT was visualized as a hyperreflective deep corneal layer at the level of Descemet membrane in all eyes. The OCT color scale revealed the KF ring as a greenish, greenish-yellow, yellow, or yellow-orange band. The gray scale of AS-OCT could easily measure the length of the KF ring in patients 6 and 7.
AS-OCT is an alternative method of evaluating the KF ring in WD, which can be used in combination with slit-lamp examination. The KF ring can be easily measured using the gray scale of AS-OCT. Further studies are required to study the potential advantages of AS-OCT including assessing the density of the KF ring, as a tool to assess response to treatment in WD, in differentiating the KF ring of WD disease from copper deposits in other situations and pigmented corneal rings in non-Wilsonian liver disease.
展示威尔逊病（WD）患者凯泽-弗莱舍尔（KF）环的眼前节光学相干断层扫描（AS-OCT）结果，并探讨通过AS-OCT评估KF环的潜在优势。
这是一项回顾性病例系列研究，研究期间（2015年8月至2016年6月）在我们研究所就诊的7例患有KF环的WD患者。所有患者均接受了角膜裂隙灯检查和AS-OCT（Optovue RTVue Premier）检查。在2例患者中，使用AS-OCT的灰度测量了KF环的长度。
在所有眼中，AS-OCT灰度上的KF环在Descemet膜水平被可视化为角膜深层的高反射层。OCT彩色标尺显示KF环为绿色、绿黄色、黄色或黄橙色带。AS-OCT的灰度可以轻松测量患者6和患者7的KF环长度。
AS-OCT是评估WD中KF环的一种替代方法，可与裂隙灯检查联合使用。使用AS-OCT的灰度可以轻松测量KF环。需要进一步研究以探讨AS-OCT的潜在优势，包括评估KF环的密度，作为评估WD治疗反应的工具，区分WD疾病的KF环与其他情况下的铜沉积以及非威尔逊病性肝病中的色素性角膜环。
