Hunt Jennifer L
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mod Pathol. 2017 Jan;30(s1):S104-S111. doi: 10.1038/modpathol.2016.192.
Molecular testing in routine surgical pathology is becoming an important component of the workup of many different types of tumors. In fact, in some organ systems, guidelines now suggest that the standard of care is to obtain specific molecular panels for tumor classification and/or therapeutic planning. In the head and neck, clinically applicable molecular tests are not as abundant as in other organ systems. Most current head and neck biomarkers are utilized for diagnosis rather than as companion diagnostic tests to predict therapeutic response. As the number of potential molecular biomarker assays increases and cost pressures escalate, the pathologist must be able to navigate the molecular testing pathways. This review explores scenarios in which molecular testing might be beneficial and cost-effective in head and neck pathology.
常规外科病理学中的分子检测正成为许多不同类型肿瘤检查的重要组成部分。事实上，在某些器官系统中，目前的指南建议，治疗的标准做法是获取特定的分子检测组合用于肿瘤分类和/或治疗规划。在头颈部，临床上可应用的分子检测不如其他器官系统丰富。目前大多数头颈部生物标志物用于诊断，而非作为预测治疗反应的伴随诊断检测。随着潜在分子生物标志物检测数量的增加和成本压力的上升，病理学家必须能够在分子检测途径中找到方向。本综述探讨了分子检测在头颈部病理学中可能有益且具有成本效益的情况。
