García Joaquín J, Folpe Andrew L
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st St. SW, Rochester, MN, USA.
Head Neck Pathol. 2010 Mar;4(1):70-6. doi: 10.1007/s12105-009-0160-z. Epub 2010 Jan 22.
Recent advances in molecular pathology have had a significant impact on the diagnosis, classification, and treatment of soft tissue tumors. The practical application of these discoveries promises to assist greatly in the evaluation and treatment of soft tissue neoplasms in the head and neck region-an area characterized by exceedingly complex anatomy that often restricts the ample sampling of lesions and complete surgical resection. This reviews details some ways in which molecular techniques have strengthened conventional diagnostic and management approaches to low-grade fibromyxoid sarcoma, angiomatoid (malignant) fibrous histiocytoma, and dermatofibrosarcoma protuberans, all of which may involve the head and neck region.
分子病理学的最新进展对软组织肿瘤的诊断、分类和治疗产生了重大影响。这些发现的实际应用有望极大地帮助评估和治疗头颈部区域的软组织肿瘤，该区域解剖结构极其复杂，常常限制了对病变的充分取材和完整的手术切除。本文综述详细介绍了分子技术在哪些方面加强了对低度纤维黏液样肉瘤、血管瘤样（恶性）纤维组织细胞瘤和隆突性皮肤纤维肉瘤的传统诊断和管理方法，所有这些肿瘤都可能累及头颈部区域。
