Lewis James S
Department of Pathology, Microbiology, and Immunology; Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN, USA.
Mod Pathol. 2017 Jan;30(s1):S44-S53. doi: 10.1038/modpathol.2016.152.
As the human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma epidemic has developed in the past several decades, it has become clear that these tumors have a wide variety of morphologic tumor types and features. For the practicing pathologist, it is critical to have a working knowledge about these in order to make the correct diagnosis, not to confuse them with other lesions, and to counsel clinicians and patients on their significance (or lack of significance) for treatment and outcomes. In particular, there are a number of pitfalls and peculiarities regarding HPV-related tumors and their nodal metastases that can easily result in misclassification and confusion. This article will discuss the various morphologic types and features of HPV-related oropharyngeal carcinomas, specific differential diagnoses when challenging, and, if established, the clinical significance of each finding.
在过去几十年里，随着人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌流行情况的发展，很明显这些肿瘤有各种各样的形态学肿瘤类型和特征。对于执业病理学家来说，了解这些知识对于做出正确诊断、不将它们与其他病变混淆以及就其对治疗和预后的意义（或无意义）向临床医生和患者提供咨询至关重要。特别是，关于HPV相关肿瘤及其淋巴结转移存在一些容易导致错误分类和混淆的陷阱和特殊情况。本文将讨论HPV相关口咽癌的各种形态学类型和特征、具有挑战性时的具体鉴别诊断，以及如果确定的话，每个发现的临床意义。
