Tóth Erika
Sebészeti és Molekuláris Patológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary.
Magy Onkol. 2018 Sep 26;62(3):139-144. Epub 2018 Jul 30.
Over the past decade, human papillomavirus-related oropharyngeal squamous cell carcinoma has become a distinct entity that differs from conventional head and neck cancer in many ways including its epidemiology, genetics, tumor behavior, and prognosis. Human papillomavirus-related oropharyngeal squamous cell carcinomas also exhibit characteristic histologic features. This review will cover the histomorphologic appearances of human papillomavirus-related oropharyngeal carcinoma, with an emphasis on their differences from conventional, human papillomavirus-unrelated cancer. Besides these we summarize the mechanism of carcinogenesis and the last guidelines for diagnosing this type of cancers.
在过去十年中，人乳头瘤病毒相关的口咽鳞状细胞癌已成为一种独特的实体，在许多方面与传统的头颈癌不同，包括其流行病学、遗传学、肿瘤行为和预后。人乳头瘤病毒相关的口咽鳞状细胞癌也表现出特征性的组织学特征。本综述将涵盖人乳头瘤病毒相关口咽癌的组织形态学表现，重点是它们与传统的、与人乳头瘤病毒无关的癌症的差异。除此之外，我们总结了致癌机制以及诊断这类癌症的最新指南。
