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1
Francisella tularensis type VI secretion system comes of age.土拉弗朗西斯菌VI型分泌系统已成熟。
Virulence. 2017 Aug 18;8(6):628-631. doi: 10.1080/21505594.2016.1278336. Epub 2017 Jan 6.
2
A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control Type VI system-mediated secretion.基于诱变的方法鉴定了弗朗西斯氏土拉弗朗西斯菌 IglE N 端部分控制 VI 型系统介导分泌的关键氨基酸。
Virulence. 2017 Aug 18;8(6):821-847. doi: 10.1080/21505594.2016.1258507. Epub 2016 Nov 10.
3
Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence.土拉弗朗西斯菌IglG属于一类新型的类PAAR六型分泌系统蛋白家族，并具有毒力所需的独特N端延伸。
PLoS Pathog. 2016 Sep 7;12(9):e1005821. doi: 10.1371/journal.ppat.1005821. eCollection 2016 Sep.
4
Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence.FPI蛋白IglE的脂化作用有助于土拉热弗朗西斯菌新凶手亚种在巨噬细胞内的复制及毒力。
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Type VI Secretion System and Its Effectors PdpC, PdpD, and OpiA Contribute to Virulence in Galleria mellonella Larvae.VI 型分泌系统及其效应物 PdpC、PdpD 和 OpiA 有助于家蚕幼虫的毒力。
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Expression of Francisella pathogenicity island protein intracellular growth locus E (IglE) in mammalian cells is involved in intracellular trafficking, possibly through microtubule organizing center.弗朗西斯氏菌致病性岛蛋白细胞内生长区 E（IglE）在哺乳动物细胞中的表达涉及细胞内运输，可能通过微管组织中心。
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Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape.弗朗西斯菌需要动态型 VI 分泌系统和 ClpB 来输送效应蛋白以逃避吞噬体。
Nat Commun. 2017 Jun 16;8:15853. doi: 10.1038/ncomms15853.

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Bacteriophage SPO1 protein Gp46 suppresses functions of HU protein in .噬菌体SPO1蛋白Gp46抑制HU蛋白在……中的功能。
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Arginine 58 is indispensable for proper function of the subsp. FSC200 HU protein, and its substitution alters virulence and mediates immunity against wild-type strain.精氨酸 58 对于 subsp. FSC200 HU 蛋白的正常功能是必不可少的，其取代会改变毒力并介导针对野生型菌株的免疫。
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Disruption of the Francisella noatunensis subsp. Gene Results in Virulence Attenuation and Protection in Zebrafish.弗朗西斯氏气单胞菌亚种基因的破坏导致斑马鱼毒力减弱和保护。
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8
subsp. Releases Differentially Loaded Outer Membrane Vesicles Under Various Stress Conditions.亚种。在各种应激条件下释放不同负载的外膜囊泡。
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9
Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System.鞘磷酸化位点对非典型 VI 型分泌系统组装和功能的关键作用。
Mol Cell Proteomics. 2019 Dec;18(12):2418-2432. doi: 10.1074/mcp.RA119.001532. Epub 2019 Oct 2.
10
Innate Immune Recognition: An Issue More Complex Than Expected.先天免疫识别：比预期更复杂的问题。
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本文引用的文献

1
A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control Type VI system-mediated secretion.基于诱变的方法鉴定了弗朗西斯氏土拉弗朗西斯菌 IglE N 端部分控制 VI 型系统介导分泌的关键氨基酸。
Virulence. 2017 Aug 18;8(6):821-847. doi: 10.1080/21505594.2016.1258507. Epub 2016 Nov 10.
2
Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence.土拉弗朗西斯菌IglG属于一类新型的类PAAR六型分泌系统蛋白家族，并具有毒力所需的独特N端延伸。
PLoS Pathog. 2016 Sep 7;12(9):e1005821. doi: 10.1371/journal.ppat.1005821. eCollection 2016 Sep.
3
From the Outside-In: The Francisella tularensis Envelope and Virulence.由外而内：土拉弗朗西斯菌的包膜与毒力
Front Cell Infect Microbiol. 2015 Dec 23;5:94. doi: 10.3389/fcimb.2015.00094. eCollection 2015.
4
Atomic structure of T6SS reveals interlaced array essential to function.VI型分泌系统的原子结构揭示了对功能至关重要的交错阵列。
Cell. 2015 Feb 26;160(5):940-951. doi: 10.1016/j.cell.2015.02.005.
5
Francisella novicida pathogenicity island encoded proteins were secreted during infection of macrophage-like cells.新凶手弗朗西斯菌致病岛编码蛋白在巨噬细胞样细胞感染期间被分泌。
PLoS One. 2014 Aug 26;9(8):e105773. doi: 10.1371/journal.pone.0105773. eCollection 2014.
6
Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence.FPI蛋白IglE的脂化作用有助于土拉热弗朗西斯菌新凶手亚种在巨噬细胞内的复制及毒力。
Pathog Dis. 2014 Oct;72(1):10-8. doi: 10.1111/2049-632X.12167. Epub 2014 May 8.
7
IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A Francisella tularensis.IglE 是一种外膜相关脂蛋白，对于 A 型土拉弗朗西斯菌的细胞内存活和鼠类毒力至关重要。
Infect Immun. 2013 Nov;81(11):4026-40. doi: 10.1128/IAI.00595-13. Epub 2013 Aug 19.
8
PAAR-repeat proteins sharpen and diversify the type VI secretion system spike.PAAR 重复蛋白使 VI 型分泌系统刺突变锋利并多样化。
Nature. 2013 Aug 15;500(7462):350-353. doi: 10.1038/nature12453. Epub 2013 Aug 7.
9
Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection.土拉弗朗西斯菌 VI 型分泌系统在感染巨噬细胞期间分泌的独特底物。
PLoS One. 2012;7(11):e50473. doi: 10.1371/journal.pone.0050473. Epub 2012 Nov 20.
10
The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion.弗朗西斯氏菌致病性岛（FPI）编码蛋白 IglA、IglB、IglC、PdpB 和 DotU 的生化特性表明其在 VI 型分泌系统中发挥作用。
Microbiology (Reading). 2011 Dec;157(Pt 12):3483-3491. doi: 10.1099/mic.0.052308-0. Epub 2011 Oct 6.

Francisella tularensis type VI secretion system comes of age.

作者信息

Spidlova Petra, Stulik Jiri

机构信息

a Department of Molecular Pathology and Biology , Faculty of Military Health Sciences, University of Defence , Hradec Kralove , Czech Republic.

出版信息

Virulence. 2017 Aug 18;8(6):628-631. doi: 10.1080/21505594.2016.1278336. Epub 2017 Jan 6.

DOI:10.1080/21505594.2016.1278336
PMID:28060573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5626347/
Abstract
摘要